Anti-transglutaminase antibodies are the diagnostic marker of celiac disease, and are considered to be synthesized only by intestinal B-lymphocytes. During an infectious disease, these antibodies are transiently detected in serum. We show that these infection-triggered antibodies may not originate in the intestinal mucosa and are not an indication of celiac disease.
Serum Anti-Tissue Transglutaminase Antibodies Detected during Febrile Illness May Not Be Produced by the Intestinal Mucosa / DE LEO, Luigina; Quaglia, Sara; Ziberna, Fabiana; Vatta, Serena; Martelossi, Stefano; Maschio, Massimo; Not, Tarcisio. - In: THE JOURNAL OF PEDIATRICS. - ISSN 0022-3476. - STAMPA. - 166:3(2015), pp. 761-763. [10.1016/j.jpeds.2014.12.005]
Serum Anti-Tissue Transglutaminase Antibodies Detected during Febrile Illness May Not Be Produced by the Intestinal Mucosa
DE LEO, LUIGINA;QUAGLIA, SARA;ZIBERNA, FABIANA;VATTA, SERENA;MASCHIO, MASSIMO;NOT, TARCISIO
2015-01-01
Abstract
Anti-transglutaminase antibodies are the diagnostic marker of celiac disease, and are considered to be synthesized only by intestinal B-lymphocytes. During an infectious disease, these antibodies are transiently detected in serum. We show that these infection-triggered antibodies may not originate in the intestinal mucosa and are not an indication of celiac disease.| File | Dimensione | Formato | |
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