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EnglishA novel methodology for making drug conjugates using hyaluronan as a carrier was developed. This strategy involves a completely regioselective two-step synthesis of 6-amino-6-deoxyhyaluronan, which is then easily functionalized with drugs through a suitable linker. The case of hyaluronan–camptothecin conjugates is described, making use of a simple succinate linker. The antitumor activity of new hyaluronan derivatives prepared is at present under evaluation.
| Titolo: | Synthesis of 6-amino-6-deoxyhyaluronan as an intermediate for conjugation with carboxylate-containing compounds: application to hyaluronan-camptothecin conjugates |
| Autori: | |
| Data di pubblicazione: | 2009 |
| Rivista: | |
| Abstract: | A novel methodology for making drug conjugates using hyaluronan as a carrier was developed. This strategy involves a completely regioselective two-step synthesis of 6-amino-6-deoxyhyaluronan, which is then easily functionalized with drugs through a suitable linker. The case of hyaluronan–camptothecin conjugates is described, making use of a simple succinate linker. The antitumor activity of new hyaluronan derivatives prepared is at present under evaluation. |
| Handle: | http://hdl.handle.net/11368/2840181 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.carres.2008.09.027 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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