Selective halogenation of hyaluronan and partial halogen substitution by methotrexate led to 6-chloro-6-deoxy-6-O-methotrexylhyaluronan, a potential antitumor drug. The remaining halogen could be further substituted by a second organic carboxylate, leading to mixed esters. 6-O-Acetyl-6-O-methotrexylhyaluronan and 6-O-butyryl-6-O-methotrexylhyaluronan were thus synthesized and characterized by NMR spectroscopy.
Titolo: | Synthesis of 6-O-methotrexylhyaluronan as a drug delivery system | |
Autori: | ||
Data di pubblicazione: | 2009 | |
Rivista: | ||
Abstract: | Selective halogenation of hyaluronan and partial halogen substitution by methotrexate led to 6-chloro-6-deoxy-6-O-methotrexylhyaluronan, a potential antitumor drug. The remaining halogen could be further substituted by a second organic carboxylate, leading to mixed esters. 6-O-Acetyl-6-O-methotrexylhyaluronan and 6-O-butyryl-6-O-methotrexylhyaluronan were thus synthesized and characterized by NMR spectroscopy. | |
Handle: | http://hdl.handle.net/11368/2840182 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.carres.2008.09.021 | |
Appare nelle tipologie: | 1.1 Articolo in Rivista |
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