Polysaccharides are widely used as carriers in the field of drug delivery. We present a methodology to obtain water soluble drug-conjugates based on scleroglucan. Selective C-6 halogenation gives access to C-6 esters; conjugates between methotrexate and scleroglucan are described, potentially useful for antitumour therapy or in rheumatoid arthritis treatment.
Synthesis of 6-deoxy-6-chloro and 6-deoxy-6-bromo derivatives of scleroglucan as intermediates for conjugation with methotrexate and other carboxylate containing compounds / Marchetti, Francesco; Bergamin, Massimo; Bosi, Susanna; Khan, Riaz; Murano, Erminio; Norbedo, Stefano. - In: CARBOHYDRATE POLYMERS. - ISSN 0144-8617. - 75:4(2009), pp. 670-676. [10.1016/j.carbpol.2008.09.007]
Synthesis of 6-deoxy-6-chloro and 6-deoxy-6-bromo derivatives of scleroglucan as intermediates for conjugation with methotrexate and other carboxylate containing compounds
BOSI, Susanna;
2009-01-01
Abstract
Polysaccharides are widely used as carriers in the field of drug delivery. We present a methodology to obtain water soluble drug-conjugates based on scleroglucan. Selective C-6 halogenation gives access to C-6 esters; conjugates between methotrexate and scleroglucan are described, potentially useful for antitumour therapy or in rheumatoid arthritis treatment.Pubblicazioni consigliate
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