The main functions of biological adhesives and sealants are to repair injured tissues, reinforce surgical wounds, or even replace common suturing techniques. In general surgery, adhesives must match several requirements taking into account clinical needs, biological effects, and material features; these requirements can be fulfilled by specific polymers. Natural or synthetic polymeric materials can be employed to generate three-dimensional networks that physically or chemically bind to the target tissues and act as hemostats, sealants, or adhesives. Among them, fibrin, gelatin, dextran, chitosan, cyanoacrylates, polyethylene glycol, and polyurethanes are the most important components of these interfaces; various aspects regarding their adhesion mechanisms, mechanical performance, and resistance to body fluids should be taken into account to choose the most suitable formulation for the target application. This review aims to describe the main adhesives and sealant materials for general surgery applications developed in the past decades and to highlight the most important aspects for the development of future formulations.

Adhesive and sealant interfaces for general surgery applications

SCOGNAMIGLIO, FRANCESCA;TRAVAN, Andrea;RUSTIGHI, ISABELLA;TARCHI, PAOLA;PALMISANO, SILVIA;MARSICH, ELEONORA
;
BORGOGNA, MASSIMILIANO ANTONIO;DONATI, IVAN;de Manzini, Nicolo';PAOLETTI, SERGIO
2016

Abstract

The main functions of biological adhesives and sealants are to repair injured tissues, reinforce surgical wounds, or even replace common suturing techniques. In general surgery, adhesives must match several requirements taking into account clinical needs, biological effects, and material features; these requirements can be fulfilled by specific polymers. Natural or synthetic polymeric materials can be employed to generate three-dimensional networks that physically or chemically bind to the target tissues and act as hemostats, sealants, or adhesives. Among them, fibrin, gelatin, dextran, chitosan, cyanoacrylates, polyethylene glycol, and polyurethanes are the most important components of these interfaces; various aspects regarding their adhesion mechanisms, mechanical performance, and resistance to body fluids should be taken into account to choose the most suitable formulation for the target application. This review aims to describe the main adhesives and sealant materials for general surgery applications developed in the past decades and to highlight the most important aspects for the development of future formulations.
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https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.b.33409
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Descrizione: Post Print VQR3. This is the peer reviewed version of the following article: Scognamiglio F., Travan A., Rustighi I. et al. Adhesive and sealant interfaces for general surgery applications. J Biomed Mater Res B Appl Biomater. 2016 Apr;104(3):626-39 which has been published in final form at https://doi.org/10.1002/jbm.b.33409. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2840654
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