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EnglishThe present manuscript addresses the description of binary systems of hyaluronan (HA) and alginate (Alg) in semi-concentrated solution. The two polysaccharides were completely miscible in the entire range of relative weight fraction explored at a total polymer concentration of up to 3 % (w/V). The rheological study encompassed steady flow and mechanical spectra for HA/Alg systems at different weight fractions with hyaluronan at different molecular weights. These extensive analyses allowed us to propose a model for the molecular arrangement in solution that envisages a mutual exclusion between the two polysaccharides even though a clear phase separation does not occur. This result may have profound implications when biomaterials based on the combination of alginate and hyaluronan are proposed in the field of biomedical materials.
| Titolo: | Rheology of mixed alginate-hyaluronan aqueous solutions | |
| Autori: | ||
| Data di pubblicazione: | 2015 | |
| Rivista: | ||
| Abstract: | The present manuscript addresses the description of binary systems of hyaluronan (HA) and alginate (Alg) in semi-concentrated solution. The two polysaccharides were completely miscible in the entire range of relative weight fraction explored at a total polymer concentration of up to 3 % (w/V). The rheological study encompassed steady flow and mechanical spectra for HA/Alg systems at different weight fractions with hyaluronan at different molecular weights. These extensive analyses allowed us to propose a model for the molecular arrangement in solution that envisages a mutual exclusion between the two polysaccharides even though a clear phase separation does not occur. This result may have profound implications when biomaterials based on the combination of alginate and hyaluronan are proposed in the field of biomedical materials. | |
| Handle: | http://hdl.handle.net/11368/2840665 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.ijbiomac.2015.04.009 | |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Alginate - HA.pdf | Documento in Versione Editoriale | Digital Rights Management non definito | Administrator Richiedi una copia | |
| Post print.pdf | Bozza finale post-referaggio (post-print) |  | Open Access Visualizza/Apri |
