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EnglishInherited thrombocytopenias (IT) are a heterogeneous group of diseases caused by at least 20 different genes. At present, these genes account for approximately 50% of cases, suggesting that novel genes have yet to be identified for a comprehensive understanding of platelet biogenesis defects. This review provides an update of ITs focusing on the molecular basis and potential pathogenic mechanisms affecting megakaryopoiesis and platelet production.
| Titolo: | Molecular basis of inherited thrombocytopenias |
| Autori: | |
| Data di pubblicazione: | 2016 |
| Rivista: | |
| Abstract: | Inherited thrombocytopenias (IT) are a heterogeneous group of diseases caused by at least 20 different genes. At present, these genes account for approximately 50% of cases, suggesting that novel genes have yet to be identified for a comprehensive understanding of platelet biogenesis defects. This review provides an update of ITs focusing on the molecular basis and potential pathogenic mechanisms affecting megakaryopoiesis and platelet production. |
| Handle: | http://hdl.handle.net/11368/2841118 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/cge.12607 |
| URL: | http://onlinelibrary.wiley.com/doi/10.1111/cge.12607/abstract;jsessionid=6F41BD65F22267EF0C85DE2447CBE9A3.f03t04 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 131 review IT postprint.pdf | Bozza finale post-referaggio (post-print) | Digital Rights Management non definito | Open Access Visualizza/Apri | |
| Savoia-2016-Clinical_Genetics.pdf | Documento in Versione Editoriale | Digital Rights Management non definito | Administrator Richiedi una copia |
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