This mini-review examines key classes of short peptides capable of self-assembly into nanostructured hydrogels for biomaterial applications, with an eye for the current patent landscape. Systems reviewed are the ones based on heterochiral short peptides, N-protected peptides with aromatic moieties to induce π-π stacking (e.g., Fmoc, naphthalene), peptide amphiphiles displaying alkyl chains, amphiphilic peptides, beta-hairpin systems. Patents related to their more general use in cell culture or more tissue-specific applications are also briefly discussed. Concluding remarks on current and future developments will provide a perspective on the direction that this field is undertaking.

Recent Patents on Peptide Self-Assembled Hydrogels as Nanostructured Biomaterials

MARCHESAN, SILVIA
2014

Abstract

This mini-review examines key classes of short peptides capable of self-assembly into nanostructured hydrogels for biomaterial applications, with an eye for the current patent landscape. Systems reviewed are the ones based on heterochiral short peptides, N-protected peptides with aromatic moieties to induce π-π stacking (e.g., Fmoc, naphthalene), peptide amphiphiles displaying alkyl chains, amphiphilic peptides, beta-hairpin systems. Patents related to their more general use in cell culture or more tissue-specific applications are also briefly discussed. Concluding remarks on current and future developments will provide a perspective on the direction that this field is undertaking.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2841349
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