Abstract: Mechanochemistry is an effective method for the preparation of multicomponent crystal systems. In the present work, we propose an alternative to the established liquidassisted grinding (LAG) approach. Polymer-assisted grinding (POLAG) is demonstrated to provide a new class of catalysts for improving reaction rate and increasing product diversity during mechanochemical cocrystallization reactions. We demonstrate that POLAG provides advantages comparable to the conventional liquid-assisted process, whilst eliminating the risk of unwanted solvate formation as well as enabling control of resulting particle size. It represents a new approach for the development of functional materials through mechanochemistry, and possibly opens new routes toward the understanding of the mechanisms and pathways of mechanochemical cocrystal formation.
Titolo: | Cocrystal Formation through Mechanochemistry: from Neat and Liquid-Assisted Grinding to Polymer-Assisted Grinding |
Autori: | |
Data di pubblicazione: | 2015 |
Stato di pubblicazione: | Pubblicato |
Rivista: | |
Abstract: | Abstract: Mechanochemistry is an effective method for the preparation of multicomponent crystal systems. In the present work, we propose an alternative to the established liquidassisted grinding (LAG) approach. Polymer-assisted grinding (POLAG) is demonstrated to provide a new class of catalysts for improving reaction rate and increasing product diversity during mechanochemical cocrystallization reactions. We demonstrate that POLAG provides advantages comparable to the conventional liquid-assisted process, whilst eliminating the risk of unwanted solvate formation as well as enabling control of resulting particle size. It represents a new approach for the development of functional materials through mechanochemistry, and possibly opens new routes toward the understanding of the mechanisms and pathways of mechanochemical cocrystal formation. |
Handle: | http://hdl.handle.net/11368/2841494 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/anie.201501638 |
Appare nelle tipologie: | 1.1 Articolo in Rivista |
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Polag first.pdf | articolo completo | Documento in Versione Editoriale | Digital Rights Management non definito | Administrator Richiedi una copia |
anie_201501638_sm_miscellaneous_information.pdf | pdf supporting information | Altro materiale allegato | Digital Rights Management non definito | Administrator Richiedi una copia |
Revised_manuscript _1_.pdf | pdf articolo post-print | Bozza finale post-referaggio (post-print) | Digital Rights Management non definito | Open Access Visualizza/Apri |