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EnglishA complex interplay exists between hepatocytes and hepatic stellate cells (HSC) in hepatic fibrogenesis. The activation of HSCs after liver injury leads to production of extracellular matrix (ECM). Co-culture models could be useful to mimic the liver microenvironment. This study evaluates the effect of free fatty acids (FFA) on HSC cells and the interplay with hepatocytes via both soluble-mediator and cell–cell contact.
| Titolo: | The interplay between hepatic stellate cells and hepatocytes in an in-vitro model of NASH. |
| Autori: | |
| Data di pubblicazione: | 2015 |
| Rivista: | |
| Abstract: | A complex interplay exists between hepatocytes and hepatic stellate cells (HSC) in hepatic fibrogenesis. The activation of HSCs after liver injury leads to production of extracellular matrix (ECM). Co-culture models could be useful to mimic the liver microenvironment. This study evaluates the effect of free fatty acids (FFA) on HSC cells and the interplay with hepatocytes via both soluble-mediator and cell–cell contact. |
| Handle: | http://hdl.handle.net/11368/2843799 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.tiv.2015.07.010 |
| URL: | http://www.sciencedirect.com/science/article/pii/S088723331500171X |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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| The interplay between hepatic stellate cells and hepatocytes in an in-vitro model of NASH.pdf | pdf editoriale | Documento in Versione Editoriale | Digital Rights Management non definito | Administrator Richiedi una copia |
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http://hdl.handle.net/11368/2843799
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