Eleven cases of chronic haemolytic jaundice treated with phenobarbitone are reported. In all patients, except one, the drug caused a significant reduction of hyperbilirubinaemia in spite of the persistence of an increased haemolysis. Radioactive bilirubin (3H) kinetic studies demonstrated a bilirubin transfer defect from plasma to liver in seven patients which improved after phenobarbitone therapy along with the reduction of bilirubinaemia. It is concluded that a phenobarbitone-sensitive hepatic mechanism frequently operates in producing jaundice in chronic haemolytic syndromes.



Titolo: Phenobarbitone sensitivity of jaundice in haemolytic patients
Autori: 
PERONA, GIANNI
FREZZA, MARIO
TIRIBELLI, CLAUDIO
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Data di pubblicazione: 1973
Rivista: 
BRITISH JOURNAL OF HAEMATOLOGY  
Abstract: Eleven cases of chronic haemolytic jaundice treated with phenobarbitone are reported. In all patients, except one, the drug caused a significant reduction of hyperbilirubinaemia in spite of the persistence of an increased haemolysis. Radioactive bilirubin (3H) kinetic studies demonstrated a bilirubin transfer defect from plasma to liver in seven patients which improved after phenobarbitone therapy along with the reduction of bilirubinaemia. It is concluded that a phenobarbitone-sensitive hepatic mechanism frequently operates in producing jaundice in chronic haemolytic syndromes.
Handle: http://hdl.handle.net/11368/2844164
Digital Object Identifier (DOI): 10.1111/j.1365-2141.1973.tb01785.x
URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.1973.tb01785.x/abstract
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