Eleven cases of chronic haemolytic jaundice treated with phenobarbitone are reported. In all patients, except one, the drug caused a significant reduction of hyperbilirubinaemia in spite of the persistence of an increased haemolysis. Radioactive bilirubin (3H) kinetic studies demonstrated a bilirubin transfer defect from plasma to liver in seven patients which improved after phenobarbitone therapy along with the reduction of bilirubinaemia. It is concluded that a phenobarbitone-sensitive hepatic mechanism frequently operates in producing jaundice in chronic haemolytic syndromes.

Phenobarbitone sensitivity of jaundice in haemolytic patients

PERONA, GIANNI;FREZZA, MARIO;TIRIBELLI, CLAUDIO;
1973

Abstract

Eleven cases of chronic haemolytic jaundice treated with phenobarbitone are reported. In all patients, except one, the drug caused a significant reduction of hyperbilirubinaemia in spite of the persistence of an increased haemolysis. Radioactive bilirubin (3H) kinetic studies demonstrated a bilirubin transfer defect from plasma to liver in seven patients which improved after phenobarbitone therapy along with the reduction of bilirubinaemia. It is concluded that a phenobarbitone-sensitive hepatic mechanism frequently operates in producing jaundice in chronic haemolytic syndromes.
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.1973.tb01785.x/abstract
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2844164
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