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EnglishEleven cases of chronic haemolytic jaundice treated with phenobarbitone are reported. In all patients, except one, the drug caused a significant reduction of hyperbilirubinaemia in spite of the persistence of an increased haemolysis. Radioactive bilirubin (3H) kinetic studies demonstrated a bilirubin transfer defect from plasma to liver in seven patients which improved after phenobarbitone therapy along with the reduction of bilirubinaemia. It is concluded that a phenobarbitone-sensitive hepatic mechanism frequently operates in producing jaundice in chronic haemolytic syndromes.
| Titolo: | Phenobarbitone sensitivity of jaundice in haemolytic patients |
| Autori: | |
| Data di pubblicazione: | 1973 |
| Rivista: | |
| Abstract: | Eleven cases of chronic haemolytic jaundice treated with phenobarbitone are reported. In all patients, except one, the drug caused a significant reduction of hyperbilirubinaemia in spite of the persistence of an increased haemolysis. Radioactive bilirubin (3H) kinetic studies demonstrated a bilirubin transfer defect from plasma to liver in seven patients which improved after phenobarbitone therapy along with the reduction of bilirubinaemia. It is concluded that a phenobarbitone-sensitive hepatic mechanism frequently operates in producing jaundice in chronic haemolytic syndromes. |
| Handle: | http://hdl.handle.net/11368/2844164 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1365-2141.1973.tb01785.x |
| URL: | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.1973.tb01785.x/abstract |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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