Eleven cases of chronic haemolytic jaundice treated with phenobarbitone are reported. In all patients, except one, the drug caused a significant reduction of hyperbilirubinaemia in spite of the persistence of an increased haemolysis. Radioactive bilirubin (3H) kinetic studies demonstrated a bilirubin transfer defect from plasma to liver in seven patients which improved after phenobarbitone therapy along with the reduction of bilirubinaemia. It is concluded that a phenobarbitone-sensitive hepatic mechanism frequently operates in producing jaundice in chronic haemolytic syndromes.
Phenobarbitone sensitivity of jaundice in haemolytic patients / Perona, Gianni; Corrocher, R.; Frezza, Mario; Falezza, G. C.; Cellerino, R.; Tiribelli, Claudio; Fusaroli, A.; De Sandre, G.. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - STAMPA. - Volume 25, Issue 6:(1973), pp. 5.723-5.736. [10.1111/j.1365-2141.1973.tb01785.x]
Phenobarbitone sensitivity of jaundice in haemolytic patients
PERONA, GIANNI;FREZZA, MARIO;TIRIBELLI, CLAUDIO;
1973-01-01
Abstract
Eleven cases of chronic haemolytic jaundice treated with phenobarbitone are reported. In all patients, except one, the drug caused a significant reduction of hyperbilirubinaemia in spite of the persistence of an increased haemolysis. Radioactive bilirubin (3H) kinetic studies demonstrated a bilirubin transfer defect from plasma to liver in seven patients which improved after phenobarbitone therapy along with the reduction of bilirubinaemia. It is concluded that a phenobarbitone-sensitive hepatic mechanism frequently operates in producing jaundice in chronic haemolytic syndromes.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
