The drug mass balance, performed on the entire human body, allows building up mathematical models able to account for the simultaneous processes of in vivo drug release kinetics and ADME steps (Absorption, Distribution, Metabolism and Elimination) that determine the drug pharmacokinetics (PK). As this approach holds whatever the administration route and the delivery system considered, it could play a paramount role in the development of personalized medicine.
Mass balance: an old concept for the new challenges proposed by personalized medicine
GRASSI, Mario;ABRAMI, MICHELA;POSOCCO, BIANCA;VOINOVICH, DARIO;GRASSI, GABRIELE
2015-01-01
Abstract
The drug mass balance, performed on the entire human body, allows building up mathematical models able to account for the simultaneous processes of in vivo drug release kinetics and ADME steps (Absorption, Distribution, Metabolism and Elimination) that determine the drug pharmacokinetics (PK). As this approach holds whatever the administration route and the delivery system considered, it could play a paramount role in the development of personalized medicine.File in questo prodotto:
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