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EnglishIdiopathic nephrotic syndrome represents the most common type of primary glomerular disease in children: glucocorticoids (GCs) are the first-line therapy, even if considerable interindividual differences in thepir efficacy and side effects have been reported. Immunosuppressive and anti-inflammatory effects of these drugs are mainly due to the GC-mediated transcription regulation of pro- and anti-inflammatory genes. This mechanism of action is the result of a complex multistep pathway that involves the glucocorticoid receptor and several other proteins, encoded by polymorphic genes. Aim of this review is to highlight the current knowledge on genetic variants that could affect GC response, particularly focusing on children with idiopathic nephrotic syndrome.
| Titolo: | Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome | |
| Autori: | ||
| Data di pubblicazione: | 2015 | |
| Rivista: | ||
| Abstract: | Idiopathic nephrotic syndrome represents the most common type of primary glomerular disease in children: glucocorticoids (GCs) are the first-line therapy, even if considerable interindividual differences in thepir efficacy and side effects have been reported. Immunosuppressive and anti-inflammatory effects of these drugs are mainly due to the GC-mediated transcription regulation of pro- and anti-inflammatory genes. This mechanism of action is the result of a complex multistep pathway that involves the glucocorticoid receptor and several other proteins, encoded by polymorphic genes. Aim of this review is to highlight the current knowledge on genetic variants that could affect GC response, particularly focusing on children with idiopathic nephrotic syndrome. | |
| Handle: | http://hdl.handle.net/11368/2847554 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.2217/pgs.15.101 | |
| URL: | http://www.futuremedicine.com/loi/pgs | |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Cuzzoni et al., Pharmacogenomics 2015.pdf | pdf versione editoriale-ahead of print | Documento in Versione Editoriale | Digital Rights Management non definito | Administrator Richiedi una copia |
| Review SNI pharmacogenomics.pdf | Bozza finale post-referaggio (post-print) |  | Open Access Visualizza/Apri |
