In the present work we describe the synthetic routes for preparing unprecedented 2,5-diamido 5-membered heterocycles based on the thiophene, pyrrole and furan rings exploiting Curtius-like rearrangement reactions. Conformational analysis performed for the 2,5-diamidothiophene derivatives displayed a “closed” conformation, in which the two carbonyl O atoms are in close contact with the thiophen S atom.

2,5-Diamide-substituted five-membered heterocycles: Challenging molecular synthons

FABBRO, CHIARA;ARMANI, SIMONE;BONIFAZI, DAVIDE
2014

Abstract

In the present work we describe the synthetic routes for preparing unprecedented 2,5-diamido 5-membered heterocycles based on the thiophene, pyrrole and furan rings exploiting Curtius-like rearrangement reactions. Conformational analysis performed for the 2,5-diamidothiophene derivatives displayed a “closed” conformation, in which the two carbonyl O atoms are in close contact with the thiophen S atom.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2855741
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