Inflammation and mutation of the tumor suppressor p53 are two apparently unrelated conditions that are strongly associated with cancer initiation and progression. We recently reported that gain-of-function mutant p53 modifies the response of cancer cells to inflammatory signals by binding a cytoplasmic tumor suppressor protein involved in TNFa signaling.

Cytoplasmic gain-of-function mutant p53 contributes to inflammation-associated cancer

BELLAZZO, ARIANNA;DI MININ, GIULIO;COLLAVIN, LICIO
2015-01-01

Abstract

Inflammation and mutation of the tumor suppressor p53 are two apparently unrelated conditions that are strongly associated with cancer initiation and progression. We recently reported that gain-of-function mutant p53 modifies the response of cancer cells to inflammatory signals by binding a cytoplasmic tumor suppressor protein involved in TNFa signaling.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2855919
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