Inflammation and mutation of the tumor suppressor p53 are two apparently unrelated conditions that are strongly associated with cancer initiation and progression. We recently reported that gain-of-function mutant p53 modifies the response of cancer cells to inflammatory signals by binding a cytoplasmic tumor suppressor protein involved in TNFa signaling.
Cytoplasmic gain-of-function mutant p53 contributes to inflammation-associated cancer
BELLAZZO, ARIANNA;DI MININ, GIULIO;COLLAVIN, LICIO
2015-01-01
Abstract
Inflammation and mutation of the tumor suppressor p53 are two apparently unrelated conditions that are strongly associated with cancer initiation and progression. We recently reported that gain-of-function mutant p53 modifies the response of cancer cells to inflammatory signals by binding a cytoplasmic tumor suppressor protein involved in TNFa signaling.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Cytoplasmic gain-of-function mutant p53 contributes to inflammation-associated cancer.pdf
accesso aperto
Descrizione: This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
Tipologia:
Documento in Versione Editoriale
Licenza:
Creative commons
Dimensione
1.67 MB
Formato
Adobe PDF
|
1.67 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
