Persistent CD49d engagement in circulating CLL cells: a role for blood-borne ligands?

Benedetti, D; Tissino, E; Caldana, C; Dal Bo, M; Bomben, R; Marconi, D; Ganghammer, S; Zaja, F; Pozzato, Gabriele; Di Raimondo, F; Hartmann, T. N; Del Poeta, G; Vanmeter, A; Zucchetto, A; Espina, V; Liotta, L; Gattei, V.

doi:10.1038/leu.2015.149

CD49d, the α-chain of the integrin heterodimer α4β1 (CD49d/CD29) is expressed on cell surface of ~40% of chronic lymphocytic leukemia (CLL) cases. It mediates both cell–cell and cell–matrix adhesion through binding to the vascular cell adhesion molecule-1 (VCAM-1) and fibronectin (FN), respectively. These interactions regulate CLL cell recirculation from the blood stream to tissue sites, as well as the transmission to CLL cells of signals of pro-survival and resistance to drug-induced apoptosis.1 Consistent with this functional role in CLL, a recent worldwide meta-analysis carried out on a large patient cohort, definitely demonstrated the independent prognostic relevance of CD49d in this disease

Titolo:	Persistent CD49d engagement in circulating CLL cells: a role for blood-borne ligands?
Autori:	Benedetti, D Tissino, E Caldana, C Dal Bo, M Bomben, R Marconi, D Ganghammer, S ZAJA, FRANCESCO POZZATO, GABRIELE Di Raimondo, F Hartmann, T. N Del Poeta, G Vanmeter, A Zucchetto, A Espina, V Liotta L Gattei, V. (Corresponding) mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2016
Stato di pubblicazione:	Pubblicato
Rivista:	LEUKEMIA
Abstract:	CD49d, the α-chain of the integrin heterodimer α4β1 (CD49d/CD29) is expressed on cell surface of ~40% of chronic lymphocytic leukemia (CLL) cases. It mediates both cell–cell and cell–matrix adhesion through binding to the vascular cell adhesion molecule-1 (VCAM-1) and fibronectin (FN), respectively. These interactions regulate CLL cell recirculation from the blood stream to tissue sites, as well as the transmission to CLL cells of signals of pro-survival and resistance to drug-induced apoptosis.1 Consistent with this functional role in CLL, a recent worldwide meta-analysis carried out on a large patient cohort, definitely demonstrated the independent prognostic relevance of CD49d in this disease
Handle:	http://hdl.handle.net/11368/2865447
Digital Object Identifier (DOI):	http://dx.doi.org/10.1038/leu.2015.149
URL:	http://www.nature.com/leu/journal/v30/n2/full/leu2015149a.html
Appare nelle tipologie:	1.1 Articolo in Rivista

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