Genetic variants of matrix metalloproteases (MMPs)-1, -3, and -9, together with clinical variables, might predict the growth rate (GR) of abdominal aortic aneurysm (AAA). Genotyping of MMP-1 (1,607 Gþ/G), MMP-3 ( 1,171 6A/5A), and MMP-9 microsatellite (13–26 cytosine–adenosine repeats around -90) from peripheral blood was performed in 137 AAA patients with two AAA diameter measurements (at least 3 months to 1 year apart). When the same technique (either ultrasound or computed tomography) was used for the two measurements, yearly GR was estimated and compared with MMP genotype and clinical features by linear and binary logistic regression. Collectively, 36 patients provided 94 observations, with a median GR of 3 mm/year (interquartile range, 0–5.8); GRs in carriers of MMP-1 polymorphism G/G, G/Gþ, and Gþ/Gþ genotype were 0.3, 3.5, and 4.7mm/year, respectively (p ¼ 0.008). In linear logistic regression, the main determinant of GR was growth arrest (GA, i.e., GR ¼ 0, occurring in 32 observations, 34%). In turn, GA occurredmainly in G/G MMP-1 genotype (odds ratio, 3.9; 95% confidence interval, 1.6–9.7; p ¼ 0.002), while variables accounting for GR > 0 were MMP-1 G þ /Gþ genotype, intake of any antihypertensive drug, and MMP-3 6A/6A genotype. Carriers of none, one, or two/three of these conditions accounted for a GR of 3, 4, and 9 mm/year, respectively (p ¼ 0.001). MMP-1 (1,607 Gþ/) variant is associated to differential GR in AAA: homozygous G deletion variant shows higher GA prevalence and lower GR, while carriers of G þ /Gþ MMP-1 genotype, together with intake of antihypertensive drugs, and 6A/6A in MMP-3 present cumulative GR increase.

Growth Rate of Small Abdominal Aortic Aneurysms and Genetic Polymorphisms of Matrix MetalloProteases-1, -3, and -9

ADOVASIO, ROBERTO;CALVAGNA, Cristiano Maria;SGORLON, GIADA;ZAMOLO, FRANCESCA;MEARELLI, FILIPPO;BIOLO, GIANNI;GRASSI, GABRIELE;FIOTTI, NICOLA
2016

Abstract

Genetic variants of matrix metalloproteases (MMPs)-1, -3, and -9, together with clinical variables, might predict the growth rate (GR) of abdominal aortic aneurysm (AAA). Genotyping of MMP-1 (1,607 Gþ/G), MMP-3 ( 1,171 6A/5A), and MMP-9 microsatellite (13–26 cytosine–adenosine repeats around -90) from peripheral blood was performed in 137 AAA patients with two AAA diameter measurements (at least 3 months to 1 year apart). When the same technique (either ultrasound or computed tomography) was used for the two measurements, yearly GR was estimated and compared with MMP genotype and clinical features by linear and binary logistic regression. Collectively, 36 patients provided 94 observations, with a median GR of 3 mm/year (interquartile range, 0–5.8); GRs in carriers of MMP-1 polymorphism G/G, G/Gþ, and Gþ/Gþ genotype were 0.3, 3.5, and 4.7mm/year, respectively (p ¼ 0.008). In linear logistic regression, the main determinant of GR was growth arrest (GA, i.e., GR ¼ 0, occurring in 32 observations, 34%). In turn, GA occurredmainly in G/G MMP-1 genotype (odds ratio, 3.9; 95% confidence interval, 1.6–9.7; p ¼ 0.002), while variables accounting for GR > 0 were MMP-1 G þ /Gþ genotype, intake of any antihypertensive drug, and MMP-3 6A/6A genotype. Carriers of none, one, or two/three of these conditions accounted for a GR of 3, 4, and 9 mm/year, respectively (p ¼ 0.001). MMP-1 (1,607 Gþ/) variant is associated to differential GR in AAA: homozygous G deletion variant shows higher GA prevalence and lower GR, while carriers of G þ /Gþ MMP-1 genotype, together with intake of antihypertensive drugs, and 6A/6A in MMP-3 present cumulative GR increase.
www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1563603
File in questo prodotto:
File Dimensione Formato  
s-0035-1563603.pdf

non disponibili

Tipologia: Documento in Versione Editoriale
Licenza: Digital Rights Management non definito
Dimensione 122.7 kB
Formato Adobe PDF
122.7 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2871152
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 6
social impact