N1-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives were design, synthesized and tested for their in vitro antimycobacterial activity. The new compounds showed a moderate antimycobacterial activity against the tested strain of Mycobacterium tuberculosis H37Ra and a significant antimycobacterial activity against several mycobacteria other than tuberculosis strains.



Titolo: Antimycobacterial activity of new N1-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives
Autori: 
ZAMPIERI, DANIELE
MAMOLO, MARIA GRAZIA
VIO, LUCIANO
ROMANO, MAURIZIO
mostra contributor esterni 
Data di pubblicazione: 2016
Stato di pubblicazione: Pubblicato
Rivista: 
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS  
Abstract: N1-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives were design, synthesized and tested for their in vitro antimycobacterial activity. The new compounds showed a moderate antimycobacterial activity against the tested strain of Mycobacterium tuberculosis H37Ra and a significant antimycobacterial activity against several mycobacteria other than tuberculosis strains.
Handle: http://hdl.handle.net/11368/2875602
Digital Object Identifier (DOI): 10.1016/j.bmcl.2016.05.053
URL: http://www.sciencedirect.com/science/article/pii/S0960894X16305376
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