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EnglishProphylactic treatment regimens to prevent mother-to-child HIV transmission include protease inhibitors Lopinavir and Ritonavir. Lopinavir and Ritonavir have been reported to be able to induce intracellular oxidative stress in diverse cellular models, however scarce informations are available about protease inhibitor effects of in the central nervous system (CNS). In our study we evaluated the impact of protease inhibitors on a cell neuronal model.
| Titolo: | HIV Protease Inhibitors Apoptotic Effect in SH-SY5Y Neuronal Cell Line |
| Autori: | |
| Data di pubblicazione: | 2016 |
| Rivista: | |
| Abstract: | Prophylactic treatment regimens to prevent mother-to-child HIV transmission include protease inhibitors Lopinavir and Ritonavir. Lopinavir and Ritonavir have been reported to be able to induce intracellular oxidative stress in diverse cellular models, however scarce informations are available about protease inhibitor effects of in the central nervous system (CNS). In our study we evaluated the impact of protease inhibitors on a cell neuronal model. |
| Handle: | http://hdl.handle.net/11368/2881181 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1159/000447849 |
| URL: | http://www.karger.com/Article/FullText/447849 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Lopinavir_Ritonavir_SH.pdf | Lopinavir_Ritonavir_SH | Documento in Versione Editoriale |  | Open Access Visualizza/Apri |
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