Population genetic differentiation of height and body mass index across Europe

Robinson, Matthew R; Hemani, Gibran; Medina Gomez, Carolina; Mezzavilla, Massimo; Esko, Tonu; Shakhbazov, Konstantin; Powell, Joseph E.; Vinkhuyzen, Anna; Berndt, Sonja I.; Gustafsson, Stefan; Justice, Anne E.; Kahali, Bratati; Locke, Adam E.; Pers, Tune H.; Vedantam, Sailaja; Wood, Andrew R.; Van Rheenen, Wouter; Andreassen, Ole A.; Gasparini, Paolo; Metspalu, Andres; Van Den Berg, Leonard H.; Veldink, Jan H.; Rivadeneira, Fernando; Werge, Thomas M.; Abecasis, Goncalo R.; Boomsma, Dorret I.; Chasman, Daniel I.; De Geus, Eco J. C.; Frayling, Timothy M.; Hirschhorn, Joel N.; Hottenga, Jouke Jan; Ingelsson, Erik; Loos, Ruth J. F.; Magnusson, Patrik K. E.; Martin, Nicholas G.; Montgomery, Grant W.; North, Kari E.; Pedersen, Nancy L.; Spector, Timothy D.; Speliotes, Elizabeth K.; Goddard, Michael E.; Yang, Jian; Visscher, Peter M.

doi:10.1038/ng.3401

Across-nation differences in the mean values for complex traits are common, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P < 3.94 × 10(-8); BMI, P < 5.95 × 10(-4)), and we find an among-population genetic correlation for tall and slender individuals (r = -0.80, 95% CI = -0.95, -0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (r = 0.51; P < 0.001), but environmental differences across Europe masked genetic differentiation for BMI (P < 0.58).

Titolo:	Population genetic differentiation of height and body mass index across Europe
Autori:	Robinson, Matthew R Hemani, Gibran Medina Gomez, Carolina MEZZAVILLA, MASSIMO Esko, Tonu Shakhbazov, Konstantin Powell, Joseph E. Vinkhuyzen, Anna Berndt, Sonja I. Gustafsson, Stefan Justice, Anne E. Kahali, Bratati Locke, Adam E. Pers, Tune H. Vedantam, Sailaja Wood, Andrew R. Van Rheenen, Wouter Andreassen, Ole A. GASPARINI, PAOLO Metspalu, Andres Van Den Berg, Leonard H. Veldink, Jan H. Rivadeneira, Fernando Werge, Thomas M. Abecasis, Goncalo R. Boomsma, Dorret I. Chasman, Daniel I. De Geus, Eco J. C. Frayling, Timothy M. Hirschhorn, Joel N. Hottenga, Jouke Jan Ingelsson, Erik Loos, Ruth J. F. Magnusson, Patrik K. E. Martin, Nicholas G. Montgomery, Grant W. North, Kari E. Pedersen, Nancy L. Spector, Timothy D. Speliotes, Elizabeth K. Goddard, Michael E. Yang, Jian Visscher, Peter M. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2015
Rivista:	NATURE GENETICS
Abstract:	Across-nation differences in the mean values for complex traits are common, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P < 3.94 × 10(-8); BMI, P < 5.95 × 10(-4)), and we find an among-population genetic correlation for tall and slender individuals (r = -0.80, 95% CI = -0.95, -0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (r = 0.51; P < 0.001), but environmental differences across Europe masked genetic differentiation for BMI (P < 0.58).
Handle:	http://hdl.handle.net/11368/2881267
Digital Object Identifier (DOI):	http://dx.doi.org/10.1038/ng.3401
URL:	http://www.nature.com/ng/index.html
Appare nelle tipologie:	1.1 Articolo in Rivista

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