Two tetravalent architectures, the glycocalix 7 and the RAFT 9, presenting four residues of a GM-3 ganglioside lactone mimetic, target the host compartment of melanoma and significantly abrogate the effect induced by cancerassociated fibroblasts (CAFs) contact + hypoxia in motility and invasiveness of tumor cells. The data reported: support the involvement of glycoshingolipids (GSLs) in hypoxia and show an interesting role played by the compound 9 in targeting melanoma cells thereby interfering with melanoma progression. The unprecedented findings reported for the glycocluster 9 could contribute in shedding light on the understanding of the critical and complex interactions between tumor cells and their local environment paving the way for new therapeutic agents.

Role of a Preorganized Scaffold Presenting Four Residues of a GM-3 Lactone Mimetic on Melanoma Progression

PASQUATO, LUCIA;
2016

Abstract

Two tetravalent architectures, the glycocalix 7 and the RAFT 9, presenting four residues of a GM-3 ganglioside lactone mimetic, target the host compartment of melanoma and significantly abrogate the effect induced by cancerassociated fibroblasts (CAFs) contact + hypoxia in motility and invasiveness of tumor cells. The data reported: support the involvement of glycoshingolipids (GSLs) in hypoxia and show an interesting role played by the compound 9 in targeting melanoma cells thereby interfering with melanoma progression. The unprecedented findings reported for the glycocluster 9 could contribute in shedding light on the understanding of the critical and complex interactions between tumor cells and their local environment paving the way for new therapeutic agents.
http://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.5b00283
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2883609
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