The synthesis of the larger resorcin[5 and 6]arene macrocycles [5]OMe and [6]OMe has been realized by a Lewis acid-catalyzed condensation of 1,3-dimethoxy-2-methylbenzene with paraformaldehyde in o-dichlorobenzene as the solvent. The methoxy-resorcin[5 and 6]arenes were quantitatively demethylated by treatment with BBr3 to obtain the corresponding macrocycles with free OH groups. X-ray studies showed that in the solid state both the conformation and the packing of [6]OMe and [5]OMe are driven by C–H···O, C–H···π, and π···π interactions.
Titolo: | Improved Synthesis of Larger Resorcinarenes | |
Autori: | ||
Data di pubblicazione: | 2016 | |
Rivista: | ||
Abstract: | The synthesis of the larger resorcin[5 and 6]arene macrocycles [5]OMe and [6]OMe has been realized by a Lewis acid-catalyzed condensation of 1,3-dimethoxy-2-methylbenzene with paraformaldehyde in o-dichlorobenzene as the solvent. The methoxy-resorcin[5 and 6]arenes were quantitatively demethylated by treatment with BBr3 to obtain the corresponding macrocycles with free OH groups. X-ray studies showed that in the solid state both the conformation and the packing of [6]OMe and [5]OMe are driven by C–H···O, C–H···π, and π···π interactions. | |
Handle: | http://hdl.handle.net/11368/2889722 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/acs.joc.6b00803 | |
URL: | http://pubs.acs.org/doi/suppl/10.1021/acs.joc.6b00803 | |
Appare nelle tipologie: | 1.1 Articolo in Rivista |
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