H2O2 Causes Improved Adhesion Between a Polysaccharide-based Membrane and Intestinal Serosa

In this work, hydrogen peroxide (H2O2) was employed to improve the adhesion of an alginate-based membrane to intestinal serosa: mechanical adhesion test and SEC-MALLS studies were performed to investigate the contribution of H2O2-induced modifications of both tissue and membrane to the adhesion enhancement. Adhesion tests confirmed that the formation of an adhesive gelatin layer on serosa plays a major role in increasing adhesion forces, while SEC-MALLS studies revealed a slight decrease of alginate molecular weight. However, the latter chain degradation does not seem to significantly impair the adhesion strength. Overall, this study describes a possible strategy to create adhesive interfaces between biomaterials and collagen-containing tissues