Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development

Pontillo, Alessandra; Bricher, P.; Leal, V. N. C.; Lima, S.; Souza, P. R. E.; Crovella, Sergio

doi:10.1002/jmv.24514

Only a small proportion of HPV+ women develop virus-associated lesions and cervical cancer, suggesting that other factors are involved in HPV+ keratinocyte transformation. Immune response plays an important role in clearing HPV infection, and host genetic variants resulting in defective immune response have been associated with virus persistence and/or cervical cancer. Considering that genetic variations in inflammasome genes were previously associated with viral infection and cancer development, the present study investigates selected single nucleotide polymorphisms (SNPs) in inflammasome genes as a possible risk factor for HPV infection susceptibility and/or for progression to cervical cancer.

Titolo:	Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development
Autori:	PONTILLO, Alessandra Bricher, P. Leal, V. N. C. Lima, S. Souza, P. R. E. CROVELLA, SERGIO mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2016
Rivista:	JOURNAL OF MEDICAL VIROLOGY
Abstract:	Only a small proportion of HPV+ women develop virus-associated lesions and cervical cancer, suggesting that other factors are involved in HPV+ keratinocyte transformation. Immune response plays an important role in clearing HPV infection, and host genetic variants resulting in defective immune response have been associated with virus persistence and/or cervical cancer. Considering that genetic variations in inflammasome genes were previously associated with viral infection and cancer development, the present study investigates selected single nucleotide polymorphisms (SNPs) in inflammasome genes as a possible risk factor for HPV infection susceptibility and/or for progression to cervical cancer.
Handle:	http://hdl.handle.net/11368/2893980
Digital Object Identifier (DOI):	http://dx.doi.org/10.1002/jmv.24514
URL:	http://onlinelibrary.wiley.com/doi/10.1002/jmv.24514/abstract
Appare nelle tipologie:	1.1 Articolo in Rivista

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