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EnglishOnly a small proportion of HPV+ women develop virus-associated lesions and cervical cancer, suggesting that other factors are involved in HPV+ keratinocyte transformation. Immune response plays an important role in clearing HPV infection, and host genetic variants resulting in defective immune response have been associated with virus persistence and/or cervical cancer. Considering that genetic variations in inflammasome genes were previously associated with viral infection and cancer development, the present study investigates selected single nucleotide polymorphisms (SNPs) in inflammasome genes as a possible risk factor for HPV infection susceptibility and/or for progression to cervical cancer.
| Titolo: | Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development |
| Autori: | |
| Data di pubblicazione: | 2016 |
| Rivista: | |
| Abstract: | Only a small proportion of HPV+ women develop virus-associated lesions and cervical cancer, suggesting that other factors are involved in HPV+ keratinocyte transformation. Immune response plays an important role in clearing HPV infection, and host genetic variants resulting in defective immune response have been associated with virus persistence and/or cervical cancer. Considering that genetic variations in inflammasome genes were previously associated with viral infection and cancer development, the present study investigates selected single nucleotide polymorphisms (SNPs) in inflammasome genes as a possible risk factor for HPV infection susceptibility and/or for progression to cervical cancer. |
| Handle: | http://hdl.handle.net/11368/2893980 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/jmv.24514 |
| URL: | http://onlinelibrary.wiley.com/doi/10.1002/jmv.24514/abstract |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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| HPV_INFLAMMASOME_Pontillo_et_al-2016-Journal_of_Medical_Virology.pdf | Documento in Versione Editoriale | Digital Rights Management non definito | Administrator Richiedi una copia |
