Only a small proportion of HPV+ women develop virus-associated lesions and cervical cancer, suggesting that other factors are involved in HPV+ keratinocyte transformation. Immune response plays an important role in clearing HPV infection, and host genetic variants resulting in defective immune response have been associated with virus persistence and/or cervical cancer. Considering that genetic variations in inflammasome genes were previously associated with viral infection and cancer development, the present study investigates selected single nucleotide polymorphisms (SNPs) in inflammasome genes as a possible risk factor for HPV infection susceptibility and/or for progression to cervical cancer.



Titolo: Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development
Autori: 
PONTILLO, Alessandra
CROVELLA, SERGIO
mostra contributor esterni 
Data di pubblicazione: 2016
Rivista: 
JOURNAL OF MEDICAL VIROLOGY  
Abstract: Only a small proportion of HPV+ women develop virus-associated lesions and cervical cancer, suggesting that other factors are involved in HPV+ keratinocyte transformation. Immune response plays an important role in clearing HPV infection, and host genetic variants resulting in defective immune response have been associated with virus persistence and/or cervical cancer. Considering that genetic variations in inflammasome genes were previously associated with viral infection and cancer development, the present study investigates selected single nucleotide polymorphisms (SNPs) in inflammasome genes as a possible risk factor for HPV infection susceptibility and/or for progression to cervical cancer.
Handle: http://hdl.handle.net/11368/2893980
Digital Object Identifier (DOI): 10.1002/jmv.24514
URL: http://onlinelibrary.wiley.com/doi/10.1002/jmv.24514/abstract
Appare nelle tipologie:1.1 Articolo in Rivista

File in questo prodotto:
FileDescrizioneTipologiaLicenza 
HPV_INFLAMMASOME_Pontillo_et_al-2016-Journal_of_Medical_Virology.pdf Publisher-VersionDigital Rights Management non definitoAdministrator   Richiedi una copia
Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11368/2893980
  • Citazioni

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
 
 
 
©2014 University of Trieste dove siamo Privacy
Piazzale Europa,1 34127 Trieste, Italia - Tel. +39 040.558.7111 - P.IVA 00211830328 - C.F. 80013890324 - P.E.C.: ateneo@pec.units.it
 Copyright © 2020