The DEFB1 gene, encoding for the constitutively expressed human β-defensin 1 (hBD1) antimicrobial peptide is a potential candidate when studying genetic susceptibility to caries. DEFB1 genetic variations have been reported as contributing to hBD1 production impairment, leading to a greater susceptibility to be infected by oral pathogens, also leading to periodontitis.
Caries and Innate Immunity: DEFB1 Gene Polymorphisms and Caries Susceptibility in Genetic Isolates from North-Eastern Italy / Navarra, Chiara O; Robino, Antonietta; Pirastu, Nicola; Bevilacqua, Lorenzo; Gasparini, Paolo; DI LENARDA, Roberto; Crovella, Sergio. - In: CARIES RESEARCH. - ISSN 0008-6568. - 50:6(2016), pp. 589-594. [10.1159/000450965]
Caries and Innate Immunity: DEFB1 Gene Polymorphisms and Caries Susceptibility in Genetic Isolates from North-Eastern Italy
BEVILACQUA, LORENZO;GASPARINI, PAOLO;DI LENARDA, Roberto;CROVELLA, SERGIO
2016-01-01
Abstract
The DEFB1 gene, encoding for the constitutively expressed human β-defensin 1 (hBD1) antimicrobial peptide is a potential candidate when studying genetic susceptibility to caries. DEFB1 genetic variations have been reported as contributing to hBD1 production impairment, leading to a greater susceptibility to be infected by oral pathogens, also leading to periodontitis.| File | Dimensione | Formato | |
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DEFB1_Caries_Research_def.pdf
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Caries_Research_Supp_Mat_def.pdf
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