Chronic recurrent multifocal osteomyelitis (CRMO) is a rare inflammatory disorder that primarily affects children. Pathogenesis is still unknown. It is characterized by insidious onset of pain, local bone expansion and radiological findings suggestive of osteomyelitis at multiple sites. CRMO predominantly affects metaphyses of long bones but clavicle and mandible are suggestive of diagnosis. CRMO is a diagnosis of exclusion. Differential diagnosis includes infectious, malignancies, benign bone tumors, metabolic disorders and other autoinflammatory disorders, so a biopsy of the bone lesion is required. NSAIDs are the first-choice treatment. Alternative therapies have been used, including corticosteroids, methotrexate, bisphosphonates and TNF alpha-inhibitors. The paper reports one case of involvement of mandible, reviews the literature and describes the experience with CRMO over the past ten years.

L'osteomielite cronica multifocale ricorrente: Se la conosci la riconosci

TADDIO, ANDREA;VENTURA, ALESSANDRO
2014

Abstract

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare inflammatory disorder that primarily affects children. Pathogenesis is still unknown. It is characterized by insidious onset of pain, local bone expansion and radiological findings suggestive of osteomyelitis at multiple sites. CRMO predominantly affects metaphyses of long bones but clavicle and mandible are suggestive of diagnosis. CRMO is a diagnosis of exclusion. Differential diagnosis includes infectious, malignancies, benign bone tumors, metabolic disorders and other autoinflammatory disorders, so a biopsy of the bone lesion is required. NSAIDs are the first-choice treatment. Alternative therapies have been used, including corticosteroids, methotrexate, bisphosphonates and TNF alpha-inhibitors. The paper reports one case of involvement of mandible, reviews the literature and describes the experience with CRMO over the past ten years.
MEDICO E BAMBINO
http://www.medicoebambino.com/?id=1407_415.pdf
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2896511
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact