To evaluate the rheological properties of mixtures of different commercially available ophthalmic viscosurgical devices (OVDs) containing sodium hyaluronate and chondroitin sulfate. SETTING: Eye Clinic, University of Trieste, Trieste, Italy. DESIGN: Laboratory study. METHODS: Blends were obtained combining a superviscous cohesive OVD (Healon GV [sodium hyaluronate 1%]) and a medium-viscosity dispersive OVD (Viscoat [sodium hyaluronate 3.0%-chondroitin sulfate 4.0%]). The 2 substances were combined in different ratios, and the rheological characteristics were analyzed to find the optimum proportion. A new viscous dispersive OVD, Discovisc (hyaluronic acid 1.6%-chondroitin sulfate 4.0%) was evaluated for comparison. The storage modulus, loss modulus, crossover point, complex viscosity, shear viscosity, and pseudoplasticity were studied. RESULTS: The rheological properties of the mixed solution (1:1 and 3:1) showed intermediate characteristics in comparison with the 2 original substances, characterized by a viscosity comparable to that of the superviscous cohesive OVD, but at a higher shear rate (similar to the medium-viscosity dispersive OVD). The new viscous dispersive OVD performed similarly to the medium-viscosity dispersive OVD at low shear rates but was comparable to the superviscous cohesive OVD at high shear rates. CONCLUSIONS: The mixture of dispersive and cohesive rheological properties in a single OVD might be an advantage during cataract surgery. Copyright © 2016 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
Titolo: | Mixed polymeric systems: New ophthalmic viscosurgical device created by mixing commercially available devices | |
Autori: | ||
Data di pubblicazione: | 2017 | |
Rivista: | ||
Abstract: | To evaluate the rheological properties of mixtures of different commercially available ophthalmic viscosurgical devices (OVDs) containing sodium hyaluronate and chondroitin sulfate. SETTING: Eye Clinic, University of Trieste, Trieste, Italy. DESIGN: Laboratory study. METHODS: Blends were obtained combining a superviscous cohesive OVD (Healon GV [sodium hyaluronate 1%]) and a medium-viscosity dispersive OVD (Viscoat [sodium hyaluronate 3.0%-chondroitin sulfate 4.0%]). The 2 substances were combined in different ratios, and the rheological characteristics were analyzed to find the optimum proportion. A new viscous dispersive OVD, Discovisc (hyaluronic acid 1.6%-chondroitin sulfate 4.0%) was evaluated for comparison. The storage modulus, loss modulus, crossover point, complex viscosity, shear viscosity, and pseudoplasticity were studied. RESULTS: The rheological properties of the mixed solution (1:1 and 3:1) showed intermediate characteristics in comparison with the 2 original substances, characterized by a viscosity comparable to that of the superviscous cohesive OVD, but at a higher shear rate (similar to the medium-viscosity dispersive OVD). The new viscous dispersive OVD performed similarly to the medium-viscosity dispersive OVD at low shear rates but was comparable to the superviscous cohesive OVD at high shear rates. CONCLUSIONS: The mixture of dispersive and cohesive rheological properties in a single OVD might be an advantage during cataract surgery. Copyright © 2016 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved. | |
Handle: | http://hdl.handle.net/11368/2897986 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jcrs.2016.11.035 | |
URL: | http://www.sciencedirect.com/science/article/pii/S0886335016305843 | |
Appare nelle tipologie: | 1.1 Articolo in Rivista |
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