Objective: The aim of this work is to provide an in-depth investigation of the impact of Low Grade Gliomas (LGG) and their surgery on patients’ cognitive and emotional functioning and wellbeing, carried out via a comprehensive and multiple-measure psychological and neuropsychological assessment. Patients and Methods: Fifty surgically treated LGG patients were evaluated 40 months after surgery on their functioning over six different cognitive domains, three core affective/emotional aspects, and three different psychological well-being measures to obtain a clearer picture of the long-term impact of illness and surgery on their psychological and relational world. Close relatives were also involved to obtain an independent measure of the psychological dimensions investigated. Results: Cognitive status was very satisfactory with only mild Short Term Memory difficulties. The affective and well-being profile was characterized by mild signs of depression, good satisfaction with life and psychological well-being and a good personality development with patients perceiving themselves as stronger and better persons after illness. However patients reported higher emotional reactivity and psychological well-being measures were negatively affected by Epileptic Burden. Well-being was related to positive affective/emotional functioning and unrelated to cognitive functioning. Good agreement between patients and relatives was found. Conclusion: In the long term, patients operated for LGG showed good cognitive functioning, with no significant long-term cognitive sequelae for the extensive surgical approach. Psychologically, patients appear to experience a deep psychological change and maturation, closely resembling that of the so-called Post-Traumatic Growth which, to our knowledge, is for the first time described and quantified in LGG patients.

Long term cognitive functioning and psychological well being in surgically treated Low Grade Glioma patients

CAMPANELLA, FABIO;PALESE, ALVISA;DEL MISSIER, FABIO;IUS, TAMARA;FABBRO, FRANCO;
2017

Abstract

Objective: The aim of this work is to provide an in-depth investigation of the impact of Low Grade Gliomas (LGG) and their surgery on patients’ cognitive and emotional functioning and wellbeing, carried out via a comprehensive and multiple-measure psychological and neuropsychological assessment. Patients and Methods: Fifty surgically treated LGG patients were evaluated 40 months after surgery on their functioning over six different cognitive domains, three core affective/emotional aspects, and three different psychological well-being measures to obtain a clearer picture of the long-term impact of illness and surgery on their psychological and relational world. Close relatives were also involved to obtain an independent measure of the psychological dimensions investigated. Results: Cognitive status was very satisfactory with only mild Short Term Memory difficulties. The affective and well-being profile was characterized by mild signs of depression, good satisfaction with life and psychological well-being and a good personality development with patients perceiving themselves as stronger and better persons after illness. However patients reported higher emotional reactivity and psychological well-being measures were negatively affected by Epileptic Burden. Well-being was related to positive affective/emotional functioning and unrelated to cognitive functioning. Good agreement between patients and relatives was found. Conclusion: In the long term, patients operated for LGG showed good cognitive functioning, with no significant long-term cognitive sequelae for the extensive surgical approach. Psychologically, patients appear to experience a deep psychological change and maturation, closely resembling that of the so-called Post-Traumatic Growth which, to our knowledge, is for the first time described and quantified in LGG patients.
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http://www.sciencedirect.com/science/article/pii/S1878875017305016
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2901483
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