In the cure of cancer, a major cause of todayQs mortality, chemotherapy is the most common treatment, though serious frequent challenges are encountered by current anticancer drugs. We discovered that few-layer graphene (FLG) dispersions have a specific killer action on monocytes, showing neither toxic nor activation effects on other immune cells. We confirmed the therapeutic application of graphene on an aggressive type of cancer that is myelomonocytic leukemia, where the monocytes are in their malignant form. We demonstrated that graphene has the unique ability to target and boost specifically the necrosis of monocytic cancer cells. Moreover, the comparison between FLG and a common chemotherapeutic drug, etoposide, confirmed the higher specificity and toxicity of FLG. Since current chemotherapy treatments of leukemia still cause serious problems, these findings open the way to new and safer therapeutic approaches.

Few-Layer Graphene Kills Selectively Tumor Cells from Myelomonocytic Leukemia Patients

PRATO, MAURIZIO;BIANCO, ALBERTO;
2017-01-01

Abstract

In the cure of cancer, a major cause of todayQs mortality, chemotherapy is the most common treatment, though serious frequent challenges are encountered by current anticancer drugs. We discovered that few-layer graphene (FLG) dispersions have a specific killer action on monocytes, showing neither toxic nor activation effects on other immune cells. We confirmed the therapeutic application of graphene on an aggressive type of cancer that is myelomonocytic leukemia, where the monocytes are in their malignant form. We demonstrated that graphene has the unique ability to target and boost specifically the necrosis of monocytic cancer cells. Moreover, the comparison between FLG and a common chemotherapeutic drug, etoposide, confirmed the higher specificity and toxicity of FLG. Since current chemotherapy treatments of leukemia still cause serious problems, these findings open the way to new and safer therapeutic approaches.
File in questo prodotto:
File Dimensione Formato  
Russier_et_al-2017-Angewandte_Chemie_International_Edition.pdf

Accesso chiuso

Tipologia: Documento in Versione Editoriale
Licenza: Copyright Editore
Dimensione 2.74 MB
Formato Adobe PDF
2.74 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
3904_11368_2902956_EUT.pdf

Open Access dal 04/02/2018

Tipologia: Bozza finale post-referaggio (post-print)
Licenza: Digital Rights Management non definito
Dimensione 3.72 MB
Formato Adobe PDF
3.72 MB Adobe PDF Visualizza/Apri
anie201700078-sup-0001-misc_information.pdf

Accesso chiuso

Descrizione: Supporting information
Tipologia: Altro materiale allegato
Licenza: Copyright Editore
Dimensione 2.1 MB
Formato Adobe PDF
2.1 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2902956
Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 56
  • ???jsp.display-item.citation.isi??? 53
social impact