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EnglishIn the cure of cancer, a major cause of todayQs mortality, chemotherapy is the most common treatment, though serious frequent challenges are encountered by current anticancer drugs. We discovered that few-layer graphene (FLG) dispersions have a specific killer action on monocytes, showing neither toxic nor activation effects on other immune cells. We confirmed the therapeutic application of graphene on an aggressive type of cancer that is myelomonocytic leukemia, where the monocytes are in their malignant form. We demonstrated that graphene has the unique ability to target and boost specifically the necrosis of monocytic cancer cells. Moreover, the comparison between FLG and a common chemotherapeutic drug, etoposide, confirmed the higher specificity and toxicity of FLG. Since current chemotherapy treatments of leukemia still cause serious problems, these findings open the way to new and safer therapeutic approaches.
| Titolo: | Few-Layer Graphene Kills Selectively Tumor Cells from Myelomonocytic Leukemia Patients | |
| Autori: | ||
| Data di pubblicazione: | 2017 | |
| Data ahead of print: | 3-feb-2017 | |
| Stato di pubblicazione: | Pubblicato | |
| Rivista: | ||
| Abstract: | In the cure of cancer, a major cause of todayQs mortality, chemotherapy is the most common treatment, though serious frequent challenges are encountered by current anticancer drugs. We discovered that few-layer graphene (FLG) dispersions have a specific killer action on monocytes, showing neither toxic nor activation effects on other immune cells. We confirmed the therapeutic application of graphene on an aggressive type of cancer that is myelomonocytic leukemia, where the monocytes are in their malignant form. We demonstrated that graphene has the unique ability to target and boost specifically the necrosis of monocytic cancer cells. Moreover, the comparison between FLG and a common chemotherapeutic drug, etoposide, confirmed the higher specificity and toxicity of FLG. Since current chemotherapy treatments of leukemia still cause serious problems, these findings open the way to new and safer therapeutic approaches. | |
| Handle: | http://hdl.handle.net/11368/2902956 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/anie.201700078 | |
| URL: | http://onlinelibrary.wiley.com/doi/10.1002/anie.201700078/abstract | |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Russier_et_al-2017-Angewandte_Chemie_International_Edition.pdf | Documento in Versione Editoriale | Copyright Editore | Administrator Richiedi una copia | |
| 3904_11368_2902956_EUT.pdf | Bozza finale post-referaggio (post-print) | Digital Rights Management non definito | Open Access Visualizza/Apri | |
| anie201700078-sup-0001-misc_information.pdf | Supporting information | Altro materiale allegato | Copyright Editore | Administrator Richiedi una copia |
