Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor 2, has demonstrated encouraging anti-cancer activity in gastric cancer within both in vitro and in vivo models. AREAS COVERED: Apatinib's efficacy, tolerability and safety have been evaluated in one Phase II and one Phase III study in metastatic/advanced gastric cancer. In this review, we focus on the mechanism of action of apatinib, its pharmacokinetic profile and its clinical activity in the treatment of advanced/metastatic gastric cancer. Expert commentary: Unfortunately, as yet, there is no definitive biomarker data for apatinib in gastric cancer

Apatinib for the treatment of gastric cancer

ROVIELLO, GIANDOMENICO;GENERALI, DANIELE
2016

Abstract

Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor 2, has demonstrated encouraging anti-cancer activity in gastric cancer within both in vitro and in vivo models. AREAS COVERED: Apatinib's efficacy, tolerability and safety have been evaluated in one Phase II and one Phase III study in metastatic/advanced gastric cancer. In this review, we focus on the mechanism of action of apatinib, its pharmacokinetic profile and its clinical activity in the treatment of advanced/metastatic gastric cancer. Expert commentary: Unfortunately, as yet, there is no definitive biomarker data for apatinib in gastric cancer
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http://www.tandfonline.com/doi/abs/10.1080/17474124.2016.1209407?journalCode=ierh20
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Descrizione: This is an Accepted Manuscript of an article published by Taylor & Francis Group in Expert Review of Gastroenterology and Hepatology on 15/07/2016, available online: http://www.tandfonline.com/doi/full/10.1080/17474124.2016.1209407
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2903752
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