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EnglishApatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor 2, has demonstrated encouraging anti-cancer activity in gastric cancer within both in vitro and in vivo models. AREAS COVERED: Apatinib's efficacy, tolerability and safety have been evaluated in one Phase II and one Phase III study in metastatic/advanced gastric cancer. In this review, we focus on the mechanism of action of apatinib, its pharmacokinetic profile and its clinical activity in the treatment of advanced/metastatic gastric cancer. Expert commentary: Unfortunately, as yet, there is no definitive biomarker data for apatinib in gastric cancer
| Titolo: | Apatinib for the treatment of gastric cancer |
| Autori: | |
| Data di pubblicazione: | 2016 |
| Stato di pubblicazione: | Pubblicato |
| Rivista: | |
| Abstract: | Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor 2, has demonstrated encouraging anti-cancer activity in gastric cancer within both in vitro and in vivo models. AREAS COVERED: Apatinib's efficacy, tolerability and safety have been evaluated in one Phase II and one Phase III study in metastatic/advanced gastric cancer. In this review, we focus on the mechanism of action of apatinib, its pharmacokinetic profile and its clinical activity in the treatment of advanced/metastatic gastric cancer. Expert commentary: Unfortunately, as yet, there is no definitive biomarker data for apatinib in gastric cancer |
| Handle: | http://hdl.handle.net/11368/2903752 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1080/17474124.2016.1209407 |
| URL: | http://www.tandfonline.com/doi/abs/10.1080/17474124.2016.1209407?journalCode=ierh20 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Roviello G et al., 2016 Apatinib.pdf | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Expert Review of Gastroenterology and Hepatology on 15/07/2016, available online: http://www.tandfonline.com/doi/full/10.1080/17474124.2016.1209407 | Bozza finale post-referaggio (post-print) |  | Open Access Visualizza/Apri |
| Apatinib for the treatment of gastric cancer.pdf | Documento in Versione Editoriale | Digital Rights Management non definito | Administrator Richiedi una copia |
