Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor 2, has demonstrated encouraging anti-cancer activity in gastric cancer within both in vitro and in vivo models. AREAS COVERED: Apatinib's efficacy, tolerability and safety have been evaluated in one Phase II and one Phase III study in metastatic/advanced gastric cancer. In this review, we focus on the mechanism of action of apatinib, its pharmacokinetic profile and its clinical activity in the treatment of advanced/metastatic gastric cancer. Expert commentary: Unfortunately, as yet, there is no definitive biomarker data for apatinib in gastric cancer
Apatinib for the treatment of gastric cancer
ROVIELLO, GIANDOMENICO;GENERALI, DANIELE
2016
Abstract
Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor 2, has demonstrated encouraging anti-cancer activity in gastric cancer within both in vitro and in vivo models. AREAS COVERED: Apatinib's efficacy, tolerability and safety have been evaluated in one Phase II and one Phase III study in metastatic/advanced gastric cancer. In this review, we focus on the mechanism of action of apatinib, its pharmacokinetic profile and its clinical activity in the treatment of advanced/metastatic gastric cancer. Expert commentary: Unfortunately, as yet, there is no definitive biomarker data for apatinib in gastric cancer| File | Dimensione | Formato | |
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Roviello G et al., 2016 Apatinib.pdf
embargo fino al 01/09/2017
Descrizione: This is an Accepted Manuscript of an article published by Taylor & Francis Group in Expert Review of Gastroenterology and Hepatology on 15/07/2016, available online: http://www.tandfonline.com/doi/full/10.1080/17474124.2016.1209407
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Apatinib for the treatment of gastric cancer.pdf
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