Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder, tightly associated with obesity. The histological spectrum of the disease ranges from simple steatosis to steatohepatitis, with different stages of fibrosis, and fibrosis stage is the most significant predictor of mortality in NAFLD. Liver biopsy continues to be the gold standard for its diagnosis and reliable non-invasive diagnostic tools are unavailable. We investigated the accuracy of candidate proteins, identified by an in silico approach, as biomarkers for diagnosis of fibrosis.

A simple in silico strategy identifies candidate biomarkers for the diagnosis of liver fibrosis in morbidly obese subjects

Pablo J. Giraudi
;
Sabrina E. Gambaro; Carla M. Chackelevicius; Michela Giuricin; Marta Silvestri; Daniele Macor;S. L. Crocé; Deborah Bonazza; Giorgio Soardo;Nicolò de Manzini; Fabrizio Zanconati; Claudio Tiribelli; Silvia Palmisano;Natalia Rosso
2018

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder, tightly associated with obesity. The histological spectrum of the disease ranges from simple steatosis to steatohepatitis, with different stages of fibrosis, and fibrosis stage is the most significant predictor of mortality in NAFLD. Liver biopsy continues to be the gold standard for its diagnosis and reliable non-invasive diagnostic tools are unavailable. We investigated the accuracy of candidate proteins, identified by an in silico approach, as biomarkers for diagnosis of fibrosis.
21-lug-2017
Pubblicato
http://onlinelibrary.wiley.com/doi/10.1111/liv.13505
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2906149
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