The aim was to assess whether the analysis of time-intensity curves obtained after microbubble contrast agent injection could differentiate inflammatory from fibrotic ileal strictures among patients with Crohn’s disease (CD). Sixty-five consecutive patients (40 male and 25 female; mean age ± SD, 42.2 years ± 12.22) with stricture of the terminal ileal loop from CD were scanned after microbubble injection. Time-intensity curves were obtained from quantitative analysis and peak enhancement, rise time, time to peak, area under the time-intensity curve (AUC), AUC during wash-in (AUCWI), and AUC during wash-out (AUCWO) were compared between patients with inflammatory vs patients with fibrotic strictures. Inflammatory (n=40) vs fibrotic strictures (n=25) differed (P<.05) in the peak enhancement, the wash-in rate, the wash-in perfusion index, AUC, AUCWI, AUCWO. The quantitative analysis of small bowel wall contrast enhancement after microbubble contrast agent injection may differentiate inflammatory from fibrotic ileal strictures in patients with CD.

Differentiation of Inflammatory from Fibrotic Ileal Strictures Among Patients with Crohn’s Disease through Analysis of Time-intensity Curves Obtained after Microbubble Contrast Agent Injection

QUAIA, Emilio;
2017

Abstract

The aim was to assess whether the analysis of time-intensity curves obtained after microbubble contrast agent injection could differentiate inflammatory from fibrotic ileal strictures among patients with Crohn’s disease (CD). Sixty-five consecutive patients (40 male and 25 female; mean age ± SD, 42.2 years ± 12.22) with stricture of the terminal ileal loop from CD were scanned after microbubble injection. Time-intensity curves were obtained from quantitative analysis and peak enhancement, rise time, time to peak, area under the time-intensity curve (AUC), AUC during wash-in (AUCWI), and AUC during wash-out (AUCWO) were compared between patients with inflammatory vs patients with fibrotic strictures. Inflammatory (n=40) vs fibrotic strictures (n=25) differed (P<.05) in the peak enhancement, the wash-in rate, the wash-in perfusion index, AUC, AUCWI, AUCWO. The quantitative analysis of small bowel wall contrast enhancement after microbubble contrast agent injection may differentiate inflammatory from fibrotic ileal strictures in patients with CD.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2909415
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