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EnglishRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an exacerbated inflammation response, leading to tissue damage and functional disability. Zinc (Zn) is a trace element crucial for immune cell function. Low serum levels of Zn are able to increase systemic inflammation and pro-inflammatory cytokines, which exacerbate RA activity (1). The zinc transporter ZNT6 is encoded by SLC30A6 (2p22.3) and regulates Zn at the cellular level.
| Titolo: | A genetic variant within SLC30A6 has a protective role in the severity of rheumatoid arthritis |
| Autori: | |
| Data di pubblicazione: | 2016 |
| Data ahead of print: | 19-ott-2016 |
| Stato di pubblicazione: | Pubblicato |
| Rivista: | |
| Abstract: | Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an exacerbated inflammation response, leading to tissue damage and functional disability. Zinc (Zn) is a trace element crucial for immune cell function. Low serum levels of Zn are able to increase systemic inflammation and pro-inflammatory cytokines, which exacerbate RA activity (1). The zinc transporter ZNT6 is encoded by SLC30A6 (2p22.3) and regulates Zn at the cellular level. |
| Handle: | http://hdl.handle.net/11368/2921094 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1080/03009742.2016.1209551 |
| URL: | https://www.tandfonline.com/doi/abs/10.1080/03009742.2016.1209551?journalCode=irhe20 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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