Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an exacerbated inflammation response, leading to tissue damage and functional disability. Zinc (Zn) is a trace element crucial for immune cell function. Low serum levels of Zn are able to increase systemic inflammation and pro-inflammatory cytokines, which exacerbate RA activity (1). The zinc transporter ZNT6 is encoded by SLC30A6 (2p22.3) and regulates Zn at the cellular level.
A genetic variant within SLC30A6 has a protective role in the severity of rheumatoid arthritis / Adelino, J E; Addobbati, C; Pontillo, A; Fragoso, T S; Duarte, Âlbp; Crovella, S; De Azevedo Silva, J; Sandrin-Garcia, P. - In: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. - ISSN 0300-9742. - 46:4(2016), pp. 326-327. [10.1080/03009742.2016.1209551]
A genetic variant within SLC30A6 has a protective role in the severity of rheumatoid arthritis
Pontillo, A;Crovella, S;
2016-01-01
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an exacerbated inflammation response, leading to tissue damage and functional disability. Zinc (Zn) is a trace element crucial for immune cell function. Low serum levels of Zn are able to increase systemic inflammation and pro-inflammatory cytokines, which exacerbate RA activity (1). The zinc transporter ZNT6 is encoded by SLC30A6 (2p22.3) and regulates Zn at the cellular level.| File | Dimensione | Formato | |
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