Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an exacerbated inflammation response, leading to tissue damage and functional disability. Zinc (Zn) is a trace element crucial for immune cell function. Low serum levels of Zn are able to increase systemic inflammation and pro-inflammatory cytokines, which exacerbate RA activity (1). The zinc transporter ZNT6 is encoded by SLC30A6 (2p22.3) and regulates Zn at the cellular level.

A genetic variant within SLC30A6 has a protective role in the severity of rheumatoid arthritis

Pontillo, A;Crovella, S;
2016

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an exacerbated inflammation response, leading to tissue damage and functional disability. Zinc (Zn) is a trace element crucial for immune cell function. Low serum levels of Zn are able to increase systemic inflammation and pro-inflammatory cytokines, which exacerbate RA activity (1). The zinc transporter ZNT6 is encoded by SLC30A6 (2p22.3) and regulates Zn at the cellular level.
19-ott-2016
Pubblicato
https://www.tandfonline.com/doi/abs/10.1080/03009742.2016.1209551?journalCode=irhe20
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2921094
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