Host restriction factors are cellular proteins able to diminish or block viral replication in a cell-specific way. Objetive and Method: We evaluated the distribution of selected SNPs in APOBEC3G (rs3736685, rs2294367) and CUL5 (rs7117111, rs7103534, rs11212495) genes, among 264 HIV-1 infected (HIV-1+) and 259 unexposed uninfected individuals from Northeast Brazil, looking for a possible association with susceptibility to HIV-1 infection, viral load, CD4+ T cell count and success of antiretroviral therapy.
CUL5 and APOBEC3G polymorphisms are partially implicated in HIV-1 infection and antiretroviral therapy in a Brazilian population / da Silva, Ronaldo Celerino; Coelho, Antonio Victor Campos; Moura, Ronald Rodrigues; Arraes, Luiz Cláudio; Brandão, Lucas André Cavalcanti; Guimarães, Rafael Lima; Crovella, Sérgio. - In: CURRENT HIV RESEARCH. - ISSN 1873-4251. - ELETTRONICO. - 15:4(2017), pp. 245-257. [10.2174/1570162X15666170315114900]
CUL5 and APOBEC3G polymorphisms are partially implicated in HIV-1 infection and antiretroviral therapy in a Brazilian population
Crovella, Sérgio
2017-01-01
Abstract
Host restriction factors are cellular proteins able to diminish or block viral replication in a cell-specific way. Objetive and Method: We evaluated the distribution of selected SNPs in APOBEC3G (rs3736685, rs2294367) and CUL5 (rs7117111, rs7103534, rs11212495) genes, among 264 HIV-1 infected (HIV-1+) and 259 unexposed uninfected individuals from Northeast Brazil, looking for a possible association with susceptibility to HIV-1 infection, viral load, CD4+ T cell count and success of antiretroviral therapy.| File | Dimensione | Formato | |
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