We describe a 63‐year‐old Caucasian man who presented to our skin cancer unit because of a rapidly growing, ulcerated plaque on his nose, which he had first noticed 3 months previously. The ulcerated plaque involved the whole tip of the nose, which resulted in a significant disfigurement (Fig. 1). His personal and family medical history was unremarkable. He denied any type of trauma, chronic inflammation or infection at this site. On a physical examination, the lesion appeared as an indurated, infiltrating, well‐defined protruding ulcer with elevated borders, measuring 3.0 × 3.0 cm. A punch biopsy was taken and histopathology was interpreted as a well‐differentiated squamous cell carcinoma (SCC). Three weeks later, the tumour was surgically excised with a 6‐mm safety margin. Based on the histopathological examination of the whole tumour, the initial diagnosis of a well‐differentiated SCC was reversed into that of a poorly differentiated subtype without neural invasion or infiltration into the sub‐cutis. All resection margins were tumour‐free. There were no clinical signs of node involvement and further imaging, including a computed tomography of the head and neck and ultrasound of the cervical lymph nodes as well as a radiography of the chest showed no evidence of metastasis. The surgical defect was finally closed by rhinoplasty with an aesthetically and functionally good outcome. At the latest follow up of 3 years after the initial diagnosis the patient had no recurrence or metastases.

A case of disfiguring primary cutaneous squamous cell carcinoma of the nasal tip

Zalaudek, Iris
2018-01-01

Abstract

We describe a 63‐year‐old Caucasian man who presented to our skin cancer unit because of a rapidly growing, ulcerated plaque on his nose, which he had first noticed 3 months previously. The ulcerated plaque involved the whole tip of the nose, which resulted in a significant disfigurement (Fig. 1). His personal and family medical history was unremarkable. He denied any type of trauma, chronic inflammation or infection at this site. On a physical examination, the lesion appeared as an indurated, infiltrating, well‐defined protruding ulcer with elevated borders, measuring 3.0 × 3.0 cm. A punch biopsy was taken and histopathology was interpreted as a well‐differentiated squamous cell carcinoma (SCC). Three weeks later, the tumour was surgically excised with a 6‐mm safety margin. Based on the histopathological examination of the whole tumour, the initial diagnosis of a well‐differentiated SCC was reversed into that of a poorly differentiated subtype without neural invasion or infiltration into the sub‐cutis. All resection margins were tumour‐free. There were no clinical signs of node involvement and further imaging, including a computed tomography of the head and neck and ultrasound of the cervical lymph nodes as well as a radiography of the chest showed no evidence of metastasis. The surgical defect was finally closed by rhinoplasty with an aesthetically and functionally good outcome. At the latest follow up of 3 years after the initial diagnosis the patient had no recurrence or metastases.
2018
Pubblicato
https://onlinelibrary.wiley.com/doi/abs/10.1111/ajd.12686
File in questo prodotto:
File Dimensione Formato  
Giuffrida_et_al-2018-Australasian_Journal_of_Dermatology.pdf

Accesso chiuso

Tipologia: Documento in Versione Editoriale
Licenza: Copyright Editore
Dimensione 468.13 kB
Formato Adobe PDF
468.13 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2923090
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact