Cleft formation is thought to be a retraction artefact observed in histopathology due to formalin fixation dehydration. However, cleft-like retraction spaces between intraepidermal nests of melanocytes and adjacent epidermis are observed on histopathology more frequently in Spitz/Reed naevi and melanomas than in other melanocytic proliferations.
In vivo detection of peripheral clefting in melanocytic lesions
Zalaudek, I.
;
2015-01-01
Abstract
Cleft formation is thought to be a retraction artefact observed in histopathology due to formalin fixation dehydration. However, cleft-like retraction spaces between intraepidermal nests of melanocytes and adjacent epidermis are observed on histopathology more frequently in Spitz/Reed naevi and melanomas than in other melanocytic proliferations.File in questo prodotto:
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Benati_et_al-2015-British_Journal_of_Dermatology.pdf
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