Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Prins, Bram P; Mead, Timothy J; Brody, Jennifer A; Sveinbjornsson, Gardar; Ntalla, Ioanna; Bihlmeyer, Nathan A; van den Berg, Marten; Bork-Jensen, Jette; Cappellani, Stefania; Van Duijvenboden, Stefan; Klena, Nikolai T; Gabriel, George C; Liu, Xiaoqin; Gulec, Cagri; Grarup, Niels; Haessler, Jeffrey; Hall, Leanne M; Iorio, Annamaria; Isaacs, Aaron; Li-Gao, Ruifang; Lin, Honghuang; Liu, Ching-Ti; Lyytikäinen, Leo-Pekka; Marten, Jonathan; Mei, Hao; Müller-Nurasyid, Martina; Orini, Michele; Padmanabhan, Sandosh; Radmanesh, Farid; Ramirez, Julia; Robino, Antonietta; Schwartz, Molly; van Setten, Jessica; Smith, Albert V; Verweij, Niek; Warren, Helen R; Weiss, Stefan; Alonso, Alvaro; Arnar, David O; Bots, Michiel L; de Boer, Rudolf A; Dominiczak, Anna F; Eijgelsheim, Mark; Ellinor, Patrick T; Guo, Xiuqing; Felix, Stephan B; Harris, Tamara B; Hayward, Caroline; Heckbert, Susan R; Huang, Paul L; Jukema, J W; Kähönen, Mika; Kors, Jan A; Lambiase, Pier D; Launer, Lenore J; Man, Li; Linneberg, Allan; Nelson, Christopher P; Pedersen, Oluf; Perez, Marco; Peters, Annette; Polasek, Ozren; Psaty, Bruce M; Raitakari, Olli T; Rice, Kenneth M; Rotter, Jerome I; Sinner, Moritz F; Soliman, Elsayed Z; Spector, Tim D; Strauch, Konstantin; Thorsteinsdottir, Unnur; Tinker, Andrew; Trompet, Stella; Uitterlinden, André; Vaartjes, Ilonca; van der Meer, Peter; Völker, Uwe; Völzke, Henry; Waldenberger, Melanie; Wilson, James G; Xie, Zhijun; Asselbergs, Folkert W; Dörr, Marcus; van Duijn, Cornelia M; Gasparini, Paolo; Gudbjartsson, Daniel F; Gudnason, Vilmundur; Hansen, Torben; Kääb, Stefan; Kanters, Jørgen K; Kooperberg, Charles; Lehtimäki, Terho; Lin, Henry J; Lubitz, Steven A; Mook-Kanamori, Dennis O; Conti, Francesco J; Newton-Cheh, Christopher H; Rosand, Jonathan; Rudan, Igor; Samani, Nilesh J; Sinagra, Gianfranco; Smith, Blair H; Holm, Hilma; Stricker, Bruno H; Ulivi, Sheila; Sotoodehnia, Nona; Apte, Suneel S; van der Harst, Pim; Stefansson, Kari; Munroe, Patricia B; Arking, Dan E; Cecilia W, Lo; Jamshidi, Yalda

doi:10.1186/s13059-018-1457-6

Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear.

Titolo:	Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Autori:	Prins, Bram P Mead, Timothy J Brody, Jennifer A Sveinbjornsson, Gardar Ntalla, Ioanna Bihlmeyer, Nathan A van den Berg, Marten Bork-Jensen, Jette CAPPELLANI, STEFANIA Van Duijvenboden, Stefan Klena, Nikolai T Gabriel, George C Liu, Xiaoqin Gulec, Cagri Grarup, Niels Haessler, Jeffrey Hall, Leanne M IORIO, ANNAMARIA Isaacs, Aaron Li-Gao, Ruifang Lin, Honghuang Liu, Ching-Ti Lyytikäinen, Leo-Pekka Marten, Jonathan Mei, Hao Müller-Nurasyid, Martina Orini, Michele Padmanabhan, Sandosh Radmanesh, Farid Ramirez, Julia ROBINO, ANTONIETTA Schwartz, Molly van Setten, Jessica Smith, Albert V Verweij, Niek Warren, Helen R Weiss, Stefan Alonso, Alvaro Arnar, David O Bots, Michiel L de Boer, Rudolf A Dominiczak, Anna F Eijgelsheim, Mark Ellinor, Patrick T Guo, Xiuqing Felix, Stephan B Harris, Tamara B Hayward, Caroline Heckbert, Susan R Huang, Paul L Jukema, J W Kähönen, Mika Kors, Jan A Lambiase, Pier D Launer, Lenore J Li, Man Linneberg, Allan Nelson, Christopher P Pedersen, Oluf Perez, Marco Peters, Annette Polasek, Ozren Psaty, Bruce M Raitakari, Olli T Rice, Kenneth M Rotter, Jerome I Sinner, Moritz F Soliman, Elsayed Z Spector, Tim D Strauch, Konstantin Thorsteinsdottir, Unnur Tinker, Andrew Trompet, Stella Uitterlinden, André Vaartjes, Ilonca van der Meer, Peter Völker, Uwe Völzke, Henry Waldenberger, Melanie Wilson, James G Xie, Zhijun Asselbergs, Folkert W Dörr, Marcus van Duijn, Cornelia M GASPARINI, PAOLO Gudbjartsson, Daniel F Gudnason, Vilmundur Hansen, Torben Kääb, Stefan Kanters, Jørgen K Kooperberg, Charles Lehtimäki, Terho Lin, Henry J Lubitz, Steven A Mook-Kanamori, Dennis O Conti, Francesco J Newton-Cheh, Christopher H Rosand, Jonathan Rudan, Igor Samani, Nilesh J SINAGRA, GIANFRANCO Smith, Blair H Holm, Hilma Stricker, Bruno H ULIVI, SHEILA Sotoodehnia, Nona Apte, Suneel S van der Harst, Pim Stefansson, Kari Munroe, Patricia B Arking, Dan E Lo, Cecilia W Jamshidi, Yalda mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2018
Stato di pubblicazione:	Pubblicato
Rivista:	GENOME BIOLOGY
Abstract:	Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear.
Handle:	http://hdl.handle.net/11368/2929017
Digital Object Identifier (DOI):	http://dx.doi.org/10.1186/s13059-018-1457-6
URL:	https://genomebiology.biomedcentral.com/articles/10.1186/s13059-018-1457-6
Appare nelle tipologie:	1.1 Articolo in Rivista

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