Five new cyclic peptoids containing (2S,4R)-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed “submonomer/monomer” approach. Metal cations’ affinities and ion transport activities have been assessed by experimental (NMR and HPTS assay in liposomes) and computational methods. Easy functionalization of proline residues’ hydroxy groups afforded a bouquet of cyclic oligomers showing correlation between ion transport abilities and cytotoxic activities.
Tuning the biomimetic performances of 4-hydroxyproline-containing cyclic peptoids
Tosolini, M.;Tecilla, P.;
2018-01-01
Abstract
Five new cyclic peptoids containing (2S,4R)-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed “submonomer/monomer” approach. Metal cations’ affinities and ion transport activities have been assessed by experimental (NMR and HPTS assay in liposomes) and computational methods. Easy functionalization of proline residues’ hydroxy groups afforded a bouquet of cyclic oligomers showing correlation between ion transport abilities and cytotoxic activities.File in questo prodotto:
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