Aim of the Study: Radical Orchiectomy (RO) represents the standard treatment for patients (pts) with suspicious testicular masses and normal contralateral testis. Because a considerable amount of small testicular masses (STM) are benign lesions, this practice exposes to a substantial risk of overtreatment with possible medical-legal consequences. The aim of this study is to report results of testis sparing surgery (TSS) in the treatment of STM (<2 cm) and to identify an updated treatment strategy. Materials and Methods: We retrospectively reviewed clinical history of pts treated with TSS for STM <2 cm in five Italian tertiary referral centres. Demographics, pathological features and postoperative follow-up (FU) data were recorded and analysed. Results: Between Jan 2009 and Jan 2017, 147 pts have undergone TSS for STM <2 cm at diagnostic evaluation. Mean pts age was 33 (28–41) years. All diagnoses of STM were based on ultrasonographic evaluation (US), performed for pain in 25 pts, testicular mass in 20, varicocele in 15, infertility in 45 and other reasons in 42. No pts had elevated serum tumour markers. In all cases diagnosis of benign or malignant nature was achieved with frozen section examination (FSE) followed by definitive histology. Pts with benign lesions at FSE underwent TSS. Pts with malignant lesions at FSE underwent immediate RO. No grade II or higher complications according to the Clavien-Dindo classification were reported. 21 pts (14,3%) harboured malignant tumours while 126 (85,7%) benign lesions. In only two cases FSE was not confirmed by definitive pathological examination (leydigioma at FSE and mixed stromal tumour and seminoma at final pathology). FU has been scheduled according to EAU guidelines. Median FU of pts with malignant lesion was (24 months). No tumour recurrences or diffusion were reported. ROC analysis demonstrated that benign conditions were present in 92.6% of STM <1 cm and in 73,1% of STM from 1 to 2 cm (p < 0,001). Clinical and pathological features are reported in Table 1. Discussion: TSS for STM is a safe and feasible procedure. It allowed preservation of testis in the majority of pts and therefore should be considered the procedure of choice, particularly in nodules <1 cm. In pts with malignancies, during follow-up no recurrences or tumour spreading were observed when RO was preceded by TSS. At the best of our knowledge this is the largest cohort of pts and the biggest series of leydigioma treated with TSS. Guidelines on STM management should change accordingly.

Testis sparing surgery: Results of a large multicentric retrospective study

GENTILE, Giuseppe;M. Rizzo;F. Claps;G. Liguori;C. Trombetta;FRANCO, GIULIA
2018-01-01

Abstract

Aim of the Study: Radical Orchiectomy (RO) represents the standard treatment for patients (pts) with suspicious testicular masses and normal contralateral testis. Because a considerable amount of small testicular masses (STM) are benign lesions, this practice exposes to a substantial risk of overtreatment with possible medical-legal consequences. The aim of this study is to report results of testis sparing surgery (TSS) in the treatment of STM (<2 cm) and to identify an updated treatment strategy. Materials and Methods: We retrospectively reviewed clinical history of pts treated with TSS for STM <2 cm in five Italian tertiary referral centres. Demographics, pathological features and postoperative follow-up (FU) data were recorded and analysed. Results: Between Jan 2009 and Jan 2017, 147 pts have undergone TSS for STM <2 cm at diagnostic evaluation. Mean pts age was 33 (28–41) years. All diagnoses of STM were based on ultrasonographic evaluation (US), performed for pain in 25 pts, testicular mass in 20, varicocele in 15, infertility in 45 and other reasons in 42. No pts had elevated serum tumour markers. In all cases diagnosis of benign or malignant nature was achieved with frozen section examination (FSE) followed by definitive histology. Pts with benign lesions at FSE underwent TSS. Pts with malignant lesions at FSE underwent immediate RO. No grade II or higher complications according to the Clavien-Dindo classification were reported. 21 pts (14,3%) harboured malignant tumours while 126 (85,7%) benign lesions. In only two cases FSE was not confirmed by definitive pathological examination (leydigioma at FSE and mixed stromal tumour and seminoma at final pathology). FU has been scheduled according to EAU guidelines. Median FU of pts with malignant lesion was (24 months). No tumour recurrences or diffusion were reported. ROC analysis demonstrated that benign conditions were present in 92.6% of STM <1 cm and in 73,1% of STM from 1 to 2 cm (p < 0,001). Clinical and pathological features are reported in Table 1. Discussion: TSS for STM is a safe and feasible procedure. It allowed preservation of testis in the majority of pts and therefore should be considered the procedure of choice, particularly in nodules <1 cm. In pts with malignancies, during follow-up no recurrences or tumour spreading were observed when RO was preceded by TSS. At the best of our knowledge this is the largest cohort of pts and the biggest series of leydigioma treated with TSS. Guidelines on STM management should change accordingly.
2018
https://www.sciencedirect.com/science/article/pii/S1569905618330525
File in questo prodotto:
File Dimensione Formato  
Gentile.pdf

Accesso chiuso

Tipologia: Documento in Versione Editoriale
Licenza: Copyright Editore
Dimensione 54.1 kB
Formato Adobe PDF
54.1 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2936194
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact