This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma. Forty-five per cent had stage IV disease. Hepatitis C virus serology was positive in 24%. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low-risk, 34% as intermediate-risk, and 33% as high-risk. The 5-year overall survival (OS) was 69%. In univariate analysis worse OS was associated with: FLIPI (P = 0.02), age > 60 years (P = 0.05) and raised lactate dehydrogenase (P = 0.05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0.02).
Primary nodal marginal zone B-cell lymphoma: clinical features and prognostic assessment of a rare disease / Arcaini, L; Paulli, M; Burcheri, S; Rossi, A; Spina, M; Passamonti, F; Lucioni, M; Motta, T; Canzonieri, V; Montanari, M; Bonoldi, E; Gallamini, A; Uziel, L; Crugnola, M; Ramponi, A; Montanari, F; Pascutto, C; Morra, E; Lazzarino, M. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - 136:2(2007), pp. 301-304. [10.1111/j.1365-2141.2006.06437.x]
Primary nodal marginal zone B-cell lymphoma: clinical features and prognostic assessment of a rare disease
Canzonieri V;
2007-01-01
Abstract
This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma. Forty-five per cent had stage IV disease. Hepatitis C virus serology was positive in 24%. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low-risk, 34% as intermediate-risk, and 33% as high-risk. The 5-year overall survival (OS) was 69%. In univariate analysis worse OS was associated with: FLIPI (P = 0.02), age > 60 years (P = 0.05) and raised lactate dehydrogenase (P = 0.05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0.02).Pubblicazioni consigliate
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