Morphological and structural bone alterations in a rare disease

We obtained an extended description of the abnormalities present in the bone structure in a rare inherited skeletal disorders. The 3D reconstructions of the trabecular architecture in the femur, obtained by CT scans, were the starting point for the morphological evaluation and the numerical elastic characterization of two subjects: a subject whose osteopetrosis was corrected by hematopoietic stem cell transplantation several years before and a healthy control. The Bone Structure Index, a novel parameter computed from the planar radiograms of the trabecular structure in the proximal epiphysis of the hand, was also evaluated. Important differences, that were not reported in literature before, were detected in homologous portions of the subjects