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EnglishThis work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5 Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change = 0.93 +/- 0.62; Wilcoxon: p = 0.0002, n = 13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface.
| Titolo: | Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease |
| Autori: | |
| Data di pubblicazione: | 2006 |
| Stato di pubblicazione: | Pubblicato |
| Rivista: | |
| Abstract: | This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5 Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change = 0.93 +/- 0.62; Wilcoxon: p = 0.0002, n = 13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface. |
| Handle: | http://hdl.handle.net/11368/2945243 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.brainresbull.2006.08.015 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |