Transcranial direct current stimulation in two patients with Tourette syndrome

Tourette syndrome (TS) is a chronic neuropsychiatric disorder, characterized by the presence of multiple motor and phonic tics, with onset in early childhood.1 Because weak electrical currents applied to the brain induce persistent excitability changes in humans, and because neurophysiological studies document abnormal motor cortex excitability in patients with TS, we investigated whether transcranial direct current stimulation (tDCS) might reduce the frequency of these patients' tics. Here we report the results of the application of tDCS for five consecutive days in two patients with TS.