We fully agree with the authors that there is lack of validated histopathological criteria that allow to accurately differentiate well-differentiated SCC from KA. For this reason, we believe that both terms should be best avoided in the future. Therefore, we recently proposed a novel classification system, which simply differentiates whether the tumors arise within a field of cancerization and or in the absence of field cancerization. [2] We consider the former as true carcinomas with a low but existing metastatic potential.

Comment on 'The detection rate of Human Papillomavirus (HPV) in well differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma?' - Reply from authors.

Conforti C
;
PAOLINI, FEDERICO;VENUTI, ADOLFO;Zalaudek I.
2019-01-01

Abstract

We fully agree with the authors that there is lack of validated histopathological criteria that allow to accurately differentiate well-differentiated SCC from KA. For this reason, we believe that both terms should be best avoided in the future. Therefore, we recently proposed a novel classification system, which simply differentiates whether the tumors arise within a field of cancerization and or in the absence of field cancerization. [2] We consider the former as true carcinomas with a low but existing metastatic potential.
2019
2-ago-2019
Pubblicato
https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.18385
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2947509
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