Recently the first case of genital lichen sclerosus (LS) involving the vulval, perineal and perianal areas during treatment with Nivolumab was published1 . Nivolumab is a human monoclonal antibody, approved by the US Food and Drug Administration (FDA) in December 2014 for the treatment of metastatic melanoma (MM)2 . It works by inhibiting the interaction between programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1), whose unimpeded interaction downregulates T cells allowing cancer cells to evade immune surveillance.

Nivolumab-associated extragenital lichen sclerosus et atrophicus

di Meo N;Conforti C
;
Corneli P;Vezzoni R;Retrosi C;Pizzichetta MA;Magaton Rizzi G;Zalaudek I.
2020-01-01

Abstract

Recently the first case of genital lichen sclerosus (LS) involving the vulval, perineal and perianal areas during treatment with Nivolumab was published1 . Nivolumab is a human monoclonal antibody, approved by the US Food and Drug Administration (FDA) in December 2014 for the treatment of metastatic melanoma (MM)2 . It works by inhibiting the interaction between programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1), whose unimpeded interaction downregulates T cells allowing cancer cells to evade immune surveillance.
2020
9-set-2019
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https://onlinelibrary.wiley.com/doi/full/10.1111/ced.14092
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2948790
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