We report on a controlled process allowing for the gelation of a diol-rich chitosan-derivative named CTL (lactose-modified chitosan) in the presence of boric acid as the cross-linker. A two-step approach is described, namely (i) the mixing of CTL and boric acid at pH = 5, a condition where the inorganic component is mildly reactive; (ii) the addition of sodium bicarbonate (NaHCO3) as a trigger, allowing for the gradual and slow pH increase. The goal was to convert gradually the almost inert neutral boric acid into the much more reactive borate anion, the latter promoting the formation of borate esters with CTL diols. Gelling kinetics as well as mechanical behavior at small and large deformations was investigated by rheometry. CTL-boric acid gels behaved essentially as transient networks, hence continuously assembling and dissociating in a highly dynamic fashion. The present gelling mechanism preserves the strain-hardening behavior in the nonlinear region of stress-strain response, corroborating the already suggested potential applications of such gels as mimics of biological soft tissues.

PH-Assisted Gelation of Lactose-Modified Chitosan

Sacco P.
;
Furlani F.;Paoletti S.;Donati I.
2019

Abstract

We report on a controlled process allowing for the gelation of a diol-rich chitosan-derivative named CTL (lactose-modified chitosan) in the presence of boric acid as the cross-linker. A two-step approach is described, namely (i) the mixing of CTL and boric acid at pH = 5, a condition where the inorganic component is mildly reactive; (ii) the addition of sodium bicarbonate (NaHCO3) as a trigger, allowing for the gradual and slow pH increase. The goal was to convert gradually the almost inert neutral boric acid into the much more reactive borate anion, the latter promoting the formation of borate esters with CTL diols. Gelling kinetics as well as mechanical behavior at small and large deformations was investigated by rheometry. CTL-boric acid gels behaved essentially as transient networks, hence continuously assembling and dissociating in a highly dynamic fashion. The present gelling mechanism preserves the strain-hardening behavior in the nonlinear region of stress-strain response, corroborating the already suggested potential applications of such gels as mimics of biological soft tissues.
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https://pubs.acs.org/doi/10.1021/acs.biomac.9b00636
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2952839
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