Severe fetal growth restriction at 26–32 weeks : key messages from the TRUFFLE study

Bilardo, C. M.; Hecher, K.; Visser, G. H. A.; Papageorghiou, A. T.; Marlow, N.; Thilaganathan, B.; Van Wassenaer-Leemhuis, A.; Todros, T.; Marsal, K.; Frusca, T.; Arabin, B.; Brezinka, C.; Derks, J. B.; Diemert, A.; Duvekot, J. J.; Ferrazzi, E.; Ganzevoort, W.; Martinelli, P.; Ostermayer, E.; Schlembach, D.; Valensise, H.; Thornton, J.; Wolf, H.; Lees, C.; Calda, P.; Gordjin, S.; Gyselaers, W.; Klaritsch, P.; Lobmaier, S.; Manz, M.; Napolitano, R.; Prefumo, F.; Schild, R.; Stampalija, T.; Von Holsbeke, C.; Von Kaisenberg, C.

doi:10.1002/uog.18815

What was the TRUFFLE study? The Trial of Randomized Umbilical and Fetal Flow in Europe (TRUFFLE) was a prospective, multicenter, unblinded, randomized trial that ran between 1 January 2005 and 1 October 2010 in 20 European centers 1 . It studied singleton pregnancies at 26–32 weeks of gestation with a diagnosis of fetal growth restriction (FGR), defined as abdominal circumference < 10th percentile and high umbilical artery Doppler pulsatility index (PI) (> 95th percentile). In order to assess whether changes in the fetal ductus venosus (DV) Doppler waveform or short-term variation (STV) on cardiotocography (CTG) should be used as a trigger for delivery in these pregnancies, the 503 included women were randomly allocated to one of three ‘timing-of-delivery’ plans (with 1 : 1 : 1 randomization).

Severe fetal growth restriction at 26–32 weeks : key messages from the TRUFFLE study / Bilardo, C.M., Hecher, K., Visser, G.H.A., Papageorghiou, A.T., Marlow, N., Thilaganathan, B., Van Wassenaer-Leemhuis, A., Todros, T., Marsal, K., Frusca, T., Arabin, B., Brezinka, C., Derks, J.B., Diemert, A., Duvekot, J.J., Ferrazzi, E., Ganzevoort, W., Martinelli, P., Ostermayer, E., Schlembach, D., et al.. - In: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. - ISSN 0960-7692. - 50:3(2017), pp. 285-290. [10.1002/uog.18815]