This is a report concerning human polyomavirus JC (JCV) reactivation in a pediatric patient with Crohn's disease (CD) during the treatment with 5-aminosalicylic acid (5-ASA), a non-steroidal anti-inflammatory drug (NSAID). We examined 9 bioptic samples from three different bowel districts (ileum, cecum, rectum) of this child. These samples were analyzed by Quantitative PCR (Q-PCR) to investigate the presence of JCV DNA. JCV DNA was detected in one rectum biopsy taken two months after 5-ASA treatment. Although our result must be validated in a larger group of subjects and with a longer follow-up period, it underlines the importance of JCV monitoring in CD patients.
JC VIRAL REACTIVATION IN A PEDIATRIC PATIENT WITH CROHN'S DISEASE / Bellizzi, A., Barucca, V., Di Nardo, G., Fioriti, D., Fioriti, F., Iebba, V., Schippa, S., Pia Conte, M., Proietti Checchi, M., Checchi, M.P., Colosimo, M.T., Cucchiara, S., Oliva, S., Chiarini, F., Antonietta Pietropaolo, V.. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 23:3(2010), pp. 955-959. [10.1128/iai.0618111]
JC VIRAL REACTIVATION IN A PEDIATRIC PATIENT WITH CROHN'S DISEASE
Valerio Iebba;
2010-01-01
Abstract
This is a report concerning human polyomavirus JC (JCV) reactivation in a pediatric patient with Crohn's disease (CD) during the treatment with 5-aminosalicylic acid (5-ASA), a non-steroidal anti-inflammatory drug (NSAID). We examined 9 bioptic samples from three different bowel districts (ileum, cecum, rectum) of this child. These samples were analyzed by Quantitative PCR (Q-PCR) to investigate the presence of JCV DNA. JCV DNA was detected in one rectum biopsy taken two months after 5-ASA treatment. Although our result must be validated in a larger group of subjects and with a longer follow-up period, it underlines the importance of JCV monitoring in CD patients.Pubblicazioni consigliate
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