Impaired gut barrier function has been reported in some functional gastrointestinal (GI) disorders.Evidences suggest that gut microbiota affects GI motility in particular Lactobacillus species elicits anti-inflammatory activity and exerts protective effects on damage induced by pathogen Gram negative-derived lipopolysaccharide(LPS).LPS produced an oxidative imbalance in human colonic smooth muscle cells (SMC) that persists after LPS-washout and contributes to SMC morphofunctional alterations.
OP-3 The protective role of Lactobacillus Rhamnosus GG-derived factors against LPS-induced damage of human colonic smooth muscle cells / Cicenia, Alessia; F, Santagelo; Gambardella, Lucia; Iebba, Valerio; Scirocco, Annunziata; Pallotta, Lucia; Marignani, Michela; Chirletti, Piero; Carabotti, Marilia; Schippa, Serena; Corazziari, Enrico Stefano; Severi, Carola. - In: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. - ISSN 0277-2116. - STAMPA. - 61:4(2015), pp. 509-510. [10.1097/01.mpg.0000472207.54141.fa]
OP-3 The protective role of Lactobacillus Rhamnosus GG-derived factors against LPS-induced damage of human colonic smooth muscle cells
IEBBA, VALERIO;
2015-01-01
Abstract
Impaired gut barrier function has been reported in some functional gastrointestinal (GI) disorders.Evidences suggest that gut microbiota affects GI motility in particular Lactobacillus species elicits anti-inflammatory activity and exerts protective effects on damage induced by pathogen Gram negative-derived lipopolysaccharide(LPS).LPS produced an oxidative imbalance in human colonic smooth muscle cells (SMC) that persists after LPS-washout and contributes to SMC morphofunctional alterations.| File | Dimensione | Formato | |
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