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EnglishN-(4-Nitrobenzoyl)-Phe self-assembled into a transparent supramolecular hydrogel, which displayed high fibroblast and keratinocyte cell viability. The compound showed a mild antimicrobial activity against E. coli both as a hydrogel and in solution. Single-crystal XRD data revealed packing details, including protonation of the C-terminus due to an apparent pK(a) shift, as confirmed by pH titrations. MicroRaman analysis revealed almost identical features between the gel and crystal states, although more disorder in the former. The hydrogel is thermoreversible and disassembles within a range of temperatures that can be fine-tuned by experimental conditions, such as gelator concentration. At the minimum gelling concentration of 0.63 wt %, the hydrogel disassembles in a physiological temperature range of 39-42 degrees C, thus opening the way to its potential use as a biomaterial.
| Titolo: | Self-Assembly of an Amino Acid Derivative into an Antimicrobial Hydrogel Biomaterial | |
| Autori: | MARCHESAN, SILVIA (Corresponding) | |
| Data di pubblicazione: | 2020 | |
| Stato di pubblicazione: | Pubblicato | |
| Rivista: | ||
| Abstract: | N-(4-Nitrobenzoyl)-Phe self-assembled into a transparent supramolecular hydrogel, which displayed high fibroblast and keratinocyte cell viability. The compound showed a mild antimicrobial activity against E. coli both as a hydrogel and in solution. Single-crystal XRD data revealed packing details, including protonation of the C-terminus due to an apparent pK(a) shift, as confirmed by pH titrations. MicroRaman analysis revealed almost identical features between the gel and crystal states, although more disorder in the former. The hydrogel is thermoreversible and disassembles within a range of temperatures that can be fine-tuned by experimental conditions, such as gelator concentration. At the minimum gelling concentration of 0.63 wt %, the hydrogel disassembles in a physiological temperature range of 39-42 degrees C, thus opening the way to its potential use as a biomaterial. | |
| Handle: | http://hdl.handle.net/11368/2957093 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/chem.201905681 | |
| URL: | https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201905681 | |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| GarciaWiley2019.pdf | articolo pdf editoriale | Documento in Versione Editoriale | Copyright Editore | Administrator Richiedi una copia |
| chem201905681-sup-0001-misc_information.pdf | Supplementary material | Altro materiale allegato | Copyright Editore | Administrator Richiedi una copia |
